TTBK1 抗体 (C-Term)
Quick Overview for TTBK1 抗体 (C-Term) (ABIN6991059)
抗原
See all TTBK1 (Ttbk1) 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 1190-1240, C-Term
-
特异性
- Multiple isoforms of TTBK1 are known to exist. This antibody is predicted to not cross-react with TTBK2.
-
纯化方法
- TTBK1 Antibody is affinity chromatography purified via peptide column.
-
免疫原
- TTBK1 antibody was raised against a 16 amino acid synthetic peptide near the carboxy terminus of human TTBK1. The immunogen is located within amino acids 1190 - 1240 of TTBK1.
-
亚型
- IgG
-
-
anti-tau Tubulin Kinase 1 (Ttbk1) (AA 230-258), (N-Term) antibody
Ttbk1 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB24987 unconjugated
anti-tau Tubulin Kinase 1 (Ttbk1) (AA 667-695) antibodyTtbk1 适用: 人 WB 宿主: 兔 Polyclonal RB42064 unconjugated
anti-tau Tubulin Kinase 1 (Ttbk1) (C-Term) antibodyTtbk1 适用: 人, 小鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
-
TTBK1 antibody can be used for detection of TTBK1 by Western blot at 1 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.
Antibody validated: Western Blot in human samples, Immunohistochemistry in mouse samples and Immunofluorescence in human samples. All other applications and species not yet tested. -
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
浓度
- 1 mg/mL
-
缓冲液
- TTBK1 Antibody is supplied in PBS containing 0.02 % sodium azide.
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C,4 °C
-
储存方法
- TTBK1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
-
-
- TTBK1 (Ttbk1) (tau Tubulin Kinase 1 (Ttbk1))
-
别名
- TTBK1
-
背景
- TTBK1 Antibody: Tau tubulin kinase (TTBK1) belongs to the casein kinase 1 superfamily and is involved in the phosphorylation of specific serine/threonine residues in paired helical filaments of the tau protein. It is specifically expressed in the brain and induces tau aggregation in human neuronal cells in a dose-dependent manner. TTBK1 levels have been found to be upregulated in the brains of Alzheimer's disease (AD) patients, and mice expressing human TTBK1 protein showed significant age-dependent memory impairment. These mice displayed increased levels of the CDK5 activators p25 and p35, and reduced levels of the NMDA receptor types 2B and 2D, suggesting that TTBK1 may play a role in memory dysfunction in AD patients.
-
分子量
-
Predicted: 145, 151 kDa
Observed: 140 kDa -
基因ID
- 84630
-
UniProt
- Q5TCY1
抗原
-
