CRMP1 抗体 (N-Term)
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Quick Overview for CRMP1 抗体 (N-Term) (ABIN6991044)
抗原
See all CRMP1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 90-140, N-Term
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特异性
- This antibody is expected to recognize only the longest isoform of CRMP-1.
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纯化方法
- CRMP1 Antibody is affinity chromatography purified via peptide column.
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免疫原
- CRMP1 antibody was raised against a 18 amino acid synthetic peptide from near the amino terminus of human CRMP1. The immunogen is located within amino acids 90 - 140 of CRMP1.
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亚型
- IgG
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应用备注
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CRMP1 antibody can be used for the detection of CRMP1 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μ,g/mL. For immunofluorescence start at 5 μ,g/mL.
Antibody validated: Western Blot in rat samples, Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested. -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- CRMP1 Antibody is supplied in PBS containing 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,4 °C
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储存方法
- CRMP1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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- CRMP1 (Collapsin Response Mediator Protein 1 (CRMP1))
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别名
- CRMP1
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背景
- CRMP1 Antibody: Collapsin-response mediator proteins (CRMPs) are highly expressed in the developing brain where they play major roles in axonal outgrowth, neurite differentiation, and apoptosis. Their continued expression in areas of high synaptic remodeling such as the cerebellum, hippocampus, and the olfactory system suggests that these proteins may also be involved in adult brain plasticity. CRMP-1 was initially identified as a dihydro-pyrimidinase expressed exclusively in brain, later studies have shown that it is involved with neurotrophin (NT) 3-induced neurite formation and outgrowth. CRMP-1 localization switches from axonal to somatodendritic when neurons reach functional maturity, suggesting that it is involved in early neuronal differentiation as well as in later processes related to the survival or death of the newly generated neurons.
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基因ID
- 1400
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NCBI登录号
- NP_001014809
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UniProt
- Q14194
抗原
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