RNASEH2A 抗体 (AA 190-240)
Quick Overview for RNASEH2A 抗体 (AA 190-240) (ABIN6991043)
抗原
See all RNASEH2A 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 190-240
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纯化方法
- RNAse H2A Antibody is affinity chromatography purified via peptide column.
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免疫原
- RNAse H2A antibody was raised against a 17 amino acid synthetic peptide near the center of human RNAse H2A. The immunogen is located within amino acids 190 - 240 of RNAse H2A.
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亚型
- IgG
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anti-Ribonuclease H2, Subunit A (RNASEH2A) (AA 1-299) antibody
RNASEH2A 适用: 人 WB, ELISA, RNAi 宿主: 小鼠 Monoclonal 3G5-F5 unconjugated
anti-Ribonuclease H2, Subunit A (RNASEH2A) (AA 1-299) antibodyRNASEH2A 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Ribonuclease H2, Subunit A (RNASEH2A) (AA 1-301) antibodyRNASEH2A 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Ribonuclease H2, Subunit A (RNASEH2A) (C-Term) antibodyRNASEH2A 适用: 人, 斑马鱼, Cow, 马, Pig, Bat, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Ribonuclease H2, Subunit A (RNASEH2A) (AA 1-299) antibodyRNASEH2A 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Ribonuclease H2, Subunit A (RNASEH2A) (Middle Region) antibodyRNASEH2A 适用: 人, 斑马鱼 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Ribonuclease H2, Subunit A (RNASEH2A) (C-Term) antibodyRNASEH2A 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Ribonuclease H2, Subunit A (RNASEH2A) (AA 1-299) antibodyRNASEH2A 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Ribonuclease H2, Subunit A (RNASEH2A) (AA 1-301) antibodyRNASEH2A 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Ribonuclease H2, Subunit A (RNASEH2A) (C-Term) antibodyRNASEH2A 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
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RNAse H2A antibody can be used for detection of RNAse H2A by Western blot at 1 μ,g/mL. Antibody can also be used for immunocytochemistry starting at 2 μ,g/mL. For immunofluorescence start at 4 μ,g/mL.
Antibody validated: Western Blot in human samples, Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- RNAse H2A Antibody is supplied in PBS containing 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,4 °C
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储存方法
- RNAse H2A antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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- RNASEH2A (Ribonuclease H2, Subunit A (RNASEH2A))
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别名
- RNAse H2A
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背景
- RNAse H2A Antibody: Ribonucleases (RNAses) H are enzymes that hydrolyze the RNA strands of RNA/DNA hybrids. The major role of these enzymes is to remove the RNA strand from the RNA/DNA hybrids that form during DNA replication and repair. RNAse H2 is made up of three subunits, all three are required for RNAse activity. Recent evidence has demonstrated that mutations in RNAse H2A or any of the other subunits result in Aicardi-Goutieres syndrome (AGS), a neurological disorder with similar symptoms to viral brain infections including high levels of IFN-alpha in the cerebral spinal fluid. Similar conditions are observed with mutations in TREX1, a single-stranded DNA exonuclease, suggesting that RNAse H2 and TREX1 may have similar roles, and that mutations in any of these genes lead to an accumulation of intracellular nucleic acids, triggering an inflammatory response through activation of the innate immune system.
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分子量
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Predicted: 33 kDa
Observed: 33 kDa -
基因ID
- 10535
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UniProt
- O75792
抗原
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