PRTFDC1 抗体 (AA 90-140)
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北京 101111
Quick Overview for PRTFDC1 抗体 (AA 90-140) (ABIN6990967)
抗原
See all PRTFDC1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 90-140
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纯化方法
- PRTFDC1 Antibody is affinity chromatography purified via peptide column.
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免疫原
- PRTFDC1 antibody was raised against a 14 amino acid synthetic peptide from near the center of human PRTFDC1. The immunogen is located within amino acids 90 - 140 of PRTFDC1.
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亚型
- IgG
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应用备注
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PRTFDC1 antibody can be used for detection of PRTFDC1 by Western blot at 1 μ,g/mL.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested. -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- PRTFDC1 Antibody is supplied in PBS containing 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,4 °C
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储存方法
- PRTFDC1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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- PRTFDC1 (phosphoribosyl Transferase Domain Containing 1 (PRTFDC1))
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别名
- PRTFDC1
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背景
- PRTFDC1 Antibody: Phosphoribosyl transferase domain containing 1 (PRTFDC1) is highly homologous to the hypoxanthine phosphoribosyltransferase (HPRT1) and may have arisen from a gene duplication event of a common ancestor gene. Recently, it was shown that CpG islands in the PRTFDC1 promoter could be hypermethylated in ovarian cancers and oral squamous-cell carcinomas (OSCC), leading to gene silencing. Restoration of PRTFDC1 expression in OSCC inhibited cell growth in colony-formation assays, while knockdown of PRTFDC1 expression in OSCC that expressed the gene promoted cell growth. These results suggest that PRTFDC1 can act as a tumor-suppressor gene. At least three isoforms of PRTFDC1 are known to exist.
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基因ID
- 56952
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NCBI登录号
- NP_064585
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UniProt
- Q9NRG1
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途径
- Ribonucleoside Biosynthetic Process
抗原
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