Syntaphilin 抗体 (AA 350-400)
Quick Overview for Syntaphilin 抗体 (AA 350-400) (ABIN6990920)
抗原
See all Syntaphilin (SNPH) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 350-400
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纯化方法
- Syntaphilin Antibody is affinity chromatography purified via peptide column.
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免疫原
- Syntaphilin antibody was raised against a 16 amino acid synthetic peptide from near the center of human Syntaphilin. The immunogen is located within amino acids 350 - 400 of Syntaphilin.
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亚型
- IgG
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anti-Syntaphilin (SNPH) (AA 251-348) antibody
SNPH 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3B6 unconjugated
anti-Syntaphilin (SNPH) (AA 1-494) antibodySNPH 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Syntaphilin (SNPH) (AA 108-157) antibodySNPH 适用: 人, 小鼠, 大鼠, Cow, 犬, 豚鼠, 马, 兔, Bat, Hamster, 猴, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-Syntaphilin (SNPH) (AA 300-425) antibodySNPH 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Syntaphilin (SNPH) (N-Term) antibodySNPH 适用: 人, 小鼠, 大鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
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Syntaphilin antibody can be used for detection of Syntaphilin by Western blot at 1 - 2 μ,g/mL. Despite its predicted molecular weight, Syntaphilin usually migrates at higher molecular weight in SDS-PAGE. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.
Antibody validated: Western Blot in rat samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Syntaphilin Antibody is supplied in PBS containing 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,4 °C
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储存方法
- Syntaphilin antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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- Syntaphilin (SNPH)
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别名
- Syntaphilin
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背景
- Syntaphilin Antibody: Syntaphilin was initially identified in a yeast two-hybrid screen with the carboxy terminal region of Syntaxin-1 as bait. Syntaxin-1 is a key component of the synaptic vesicle docking machinery that forms the SNARE complex with synaptobrevin and SNAP-25. Syntaphilin competes with SNAP-25 for binding to syntaxin-1 and inhibits the formation of the SNARE complex, thereby potentially regulating synaptic vesicle exocytosis. Syntaphilin also binds dynamin-1 and inhibits dynamin-dependent endocytosis. Mice lacking syntaphilin show an increased level of mitochondrial motility and a reduced density of axonal mitochondria. This correlates with an enhanced short-term facilitation and significant impairments in motor ability, suggesting syntaphilin plays a major role in presynaptic function. Multiple isoforms are known to exist.
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基因ID
- 9751
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UniProt
- O15079
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途径
- Synaptic Vesicle Exocytosis
抗原
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