IRGM 抗体 (N-Term)
This anti-IRGM antibody is a 兔 多克隆 antibody detecting IRGM in WB, ELISA, IHC (p) 和 IF. Suitable for 人, 小鼠 和 大鼠.
Quick Overview for IRGM 抗体 (N-Term) (ABIN6990882)
抗原
See all IRGM 抗体
IRGM
(Immunity-Related GTPase Family, M (IRGM))
适用
人, 小鼠, 大鼠
宿主
兔
克隆类型
多克隆
标记
This IRGM antibody is un-conjugated
应用范围
Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)
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抗原表位
- AA 30-80, N-Term
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纯化方法
- IRGM Antibody is affinity chromatography purified via peptide column.
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免疫原
- IRGM antibody was raised against a 17 amino acid synthetic peptide near the amino terminus of the human IRGM. The immunogen is located within amino acids 30 - 80 of IRGM.
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亚型
- IgG
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anti-Immunity-Related GTPase Family, M (IRGM) (AA 151-179), (C-Term) antibody
IRGM 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB20841 unconjugated
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应用备注
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IRGM antibody can be used for detection of IRGM by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.
Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- IRGM Antibody is supplied in PBS containing 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,4 °C
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储存方法
- IRGM antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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- IRGM (Immunity-Related GTPase Family, M (IRGM))
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别名
- IRGM
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背景
- IRGM Antibody: Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. Two of the strongest hits implicate genes IRGM and ATG16L1, which encode proteins thought to be critical to the autophagy pathway and being significantly associated with Crohn's disease. IRGM induces autophagy and generates large autolysosomal organelles as a mechanism for the elimination of intracellular Mycobacterium tuberculosis. In mouse, IRGM belongs to a family of gamma-interferon-induced GTP-binding proteins of approximately 48 kDa that also includes IRGM2 and IRGM3, this antibody may also recognize these proteins.
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分子量
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Predicted: 20 kDa
Observed: 20 kDa -
基因ID
- 345611
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UniProt
- A1A4Y4
抗原
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