ARHGEF17 抗体 (AA 910-960)
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北京 101111
Quick Overview for ARHGEF17 抗体 (AA 910-960) (ABIN6990812)
抗原
See all ARHGEF17 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 910-960
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纯化方法
- TEM4 Antibody is affinity chromatography purified via peptide column.
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免疫原
- TEM4 antibody was raised against a 18 amino acid synthetic peptide near the center of human TEM4. The immunogen is located within amino acids 910 - 960 of TEM4.
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亚型
- IgG
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应用备注
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TEM4 antibody can be used for detection of TEM4 by Western blot at 0.5 - 1 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.
Antibody validated: Western Blot in human samples and Immunohistochemistry in human samples. All other applications and species not yet tested. -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- TEM4 Antibody is supplied in PBS containing 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,4 °C
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储存方法
- TEM4 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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- ARHGEF17 (rho Guanine Nucleotide Exchange Factor (GEF) 17 (ARHGEF17))
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别名
- TEM4
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背景
- TEM4 Antibody: Rho GTPases, which are activated by specific guanine-nucleotide exchange factors (GEFs), play pivotal roles in several cellular functions. TEM4, encoding a protein containing 1510 amino acids, contains a RhoGEF-specific Dbl homology (DH) domain but lacks their typical pleckstrin homology domain. TEM4 is a Rho-specific GEF with novel structural and regulatory properties and predominant expression in the heart. It couples tyrosine kinase signals with the activation of the rho/rac GTPases, thus leading to cell differentiation and/or proliferation. Elevated levels of TEM4, TEM5, TEM6, TEM7 and TEM7R were also raised in breast cancer tissues. TEM4 could also prove to be useful targets therapeutically.
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分子量
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Predicted: 220 kDa
Observed: 200 kDa -
基因ID
- 9828
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UniProt
- Q96PE2
抗原
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