BRCC3 抗体 (N-Term)
-
- 抗原 See all BRCC3 抗体
- BRCC3 (BRCA1/BRCA2-Containing Complex, Subunit 3 (BRCC3))
-
抗原表位
- AA 20-70, N-Term
-
适用
- 人, 小鼠, 大鼠
-
宿主
- 兔
-
克隆类型
- 多克隆
-
标记
- This BRCC3 antibody is un-conjugated
-
应用范围
- Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)
- 纯化方法
- BRCC36 Antibody is affinity chromatography purified via peptide column.
- 免疫原
- BRCC36 antibody was raised against a 18 amino acid synthetic peptide from near the amino terminus of human BRCC36. The immunogen is located within amino acids 20 - 70 of BRCC36.
- 亚型
- IgG
- Top Product
- Discover our top product BRCC3 Primary Antibody
-
anti-BRCA1/BRCA2-Containing Complex, Subunit 3 (BRCC3) (AA 14-316) antibody
BRCC3 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-BRCA1/BRCA2-Containing Complex, Subunit 3 (BRCC3) (AA 1-316) antibodyBRCC3 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-BRCA1/BRCA2-Containing Complex, Subunit 3 (BRCC3) (AA 1-316) antibodyBRCC3 适用: 人 WB, ELISA, IHC, IHC (p) 宿主: 小鼠 Monoclonal AT3B1 unconjugated
anti-BRCA1/BRCA2-Containing Complex, Subunit 3 (BRCC3) (AA 1-316), (N-Term) antibodyBRCC3 适用: 人 WB, IHC (p), EIA 宿主: 小鼠 Monoclonal AT3B1 unconjugated
anti-BRCA1/BRCA2-Containing Complex, Subunit 3 (BRCC3) (AA 1-316) antibodyBRCC3 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-BRCA1/BRCA2-Containing Complex, Subunit 3 (BRCC3) (AA 36-70) antibodyBRCC3 适用: 人 WB 宿主: 兔 Polyclonal RB54401 unconjugated
anti-BRCA1/BRCA2-Containing Complex, Subunit 3 (BRCC3) (AA 18-50) antibodyBRCC3 适用: 人 WB 宿主: 兔 Polyclonal RB53911 unconjugated
anti-BRCA1/BRCA2-Containing Complex, Subunit 3 (BRCC3) antibody (FITC)BRCC3 适用: 人 WB, ELISA, IHC, IHC (p) 宿主: 兔 Polyclonal FITC
anti-BRCA1/BRCA2-Containing Complex, Subunit 3 (BRCC3) (C-Term) antibodyBRCC3 适用: 人, 小鼠, 大鼠, 马, Pig, 猴, Cow, 豚鼠, 兔, Bat, 非洲爪蟾 WB 宿主: 兔 Polyclonal unconjugated
anti-BRCA1/BRCA2-Containing Complex, Subunit 3 (BRCC3) (C-Term) antibodyBRCC3 适用: 人, 大鼠, 马, Pig, 猴, Bat WB 宿主: 兔 Polyclonal unconjugated
-
- 应用备注
-
BRCC36 antibody can be used for detection of BRCC36 by Western blot at 0.5 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.
Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. - 限制
- 仅限研究用
-
- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- BRCC36 Antibody is supplied in PBS containing 0.02 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C,4 °C
- 储存方法
- BRCC36 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
-
- 抗原
- BRCC3 (BRCA1/BRCA2-Containing Complex, Subunit 3 (BRCC3))
- 别名
- BRCC36 (BRCC3 产品)
- 别名
- CXorf53 antibody, BRCC3 antibody, xtp1 antibody, brcc3 antibody, BRCC36 antibody, brcc36 antibody, C6.1A antibody, BRCA1/BRCA2-containing complex subunit 3 antibody, DEP domain containing 1B antibody, BRCA1/BRCA2-containing complex, subunit 3 antibody, BRCA1/BRCA2-containing complex subunit 3 L homeolog antibody, BRCC3 antibody, depdc1b antibody, brcc3 antibody, Brcc3 antibody, brcc3.L antibody
- 背景
- BRCC36 Antibody: Together with the breast and ovarian predisposition proteins BRCA1 and BRCA2 and RAD51 and BRCC45, BRCC36 forms a holoenzyme complex that possesses a ubiquitin E3 ligase activity. Aberrant levels of BRCC36 were detected in sporadic breast tumors and depletion of either BRCC36 or BRCC45 by siRNA resulted in increased sensitivity to ionizing radiation and defects in the G2/M checkpoint, indicating that BRCC36 acts to enhance cellular survival following DNA damage. Recent experiments have shown that BRCC36 is essential for ionizing radiation-induced BRCA1 phosphorylation and nuclear foci formation, suggesting that BRCC36 may be an important target in the treatment of radiation-resistant breast tumors. At least two isoforms of BRCC36 are known to exist.
- 分子量
-
Predicted: 35 kDa
Observed: 35 kDa - 基因ID
- 79184
- NCBI登录号
- NP_077308
- UniProt
- P46736
- 途径
- Positive Regulation of Response to DNA Damage Stimulus
-
