DISC1 抗体 (AA 350-400)
Quick Overview for DISC1 抗体 (AA 350-400) (ABIN6990781)
抗原
See all DISC1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 350-400
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特异性
- At least four isoforms of DISC1 are known to exist, this antibody will detect the three longest isoforms.
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纯化方法
- DISC1 Antibody is affinity chromatography purified via peptide column.
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免疫原
- DISC1 antibody was raised against an 18 amino acid synthetic peptide from near the center of human DISC1. The immunogen is located within amino acids 350 - 400 of DISC1.
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亚型
- IgG
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anti-Disrupted in Schizophrenia 1 (DISC1) (AA 102-261) antibody
DISC1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Disrupted in Schizophrenia 1 (DISC1) antibodyDISC1 适用: 人 WB, IF 宿主: 兔 Monoclonal unconjugated
anti-Disrupted in Schizophrenia 1 (DISC1) (AA 1-200) antibodyDISC1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Disrupted in Schizophrenia 1 (DISC1) (AA 99-325) antibodyDISC1 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Disrupted in Schizophrenia 1 (DISC1) (AA 461-477), (Middle Region) antibodyDISC1 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Disrupted in Schizophrenia 1 (DISC1) (AA 151-330) antibodyDISC1 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Disrupted in Schizophrenia 1 (DISC1) (AA 700-728), (C-Term) antibodyDISC1 适用: 人 WB, IHC (p), FACS, EIA 宿主: 兔 Polyclonal unconjugated
anti-Disrupted in Schizophrenia 1 (DISC1) (AA 101-200) antibodyDISC1 适用: 小鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Disrupted in Schizophrenia 1 (DISC1) (AA 761-832) antibodyDISC1 适用: 人 ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Disrupted in Schizophrenia 1 (DISC1) (N-Term) antibodyDISC1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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DISC1 antibody can be used for detection of DISC1 by Western blot at 0.5 - 2 μ,g/mL. Antibody can also be used for immunocytochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.
Antibody validated: Western Blot in human samples, Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- DISC1 Antibody is supplied in PBS containing 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,4 °C
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储存方法
- DISC1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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- DISC1 (Disrupted in Schizophrenia 1 (DISC1))
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别名
- DISC1
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背景
- DISC1 Antibody: Disrupted in schizophrenia 1 (DISC1) is a candidate gene for susceptibility to schizophrenia. It was discovered through chromosomal analysis of a large Scottish family whose members exhibited schizophrenia and related psychiatric disorders. Through yeast two-hybrid screening, it was discovered that DISC1 interacts with many members of the centrosome and cytoskeletal system including MAP1A and Nudel. More recently, DISC1 has been found to regulate the transport of a complex containing Nudel, the lissencephaly-1 (LIS1) protein, and 14-3-3epsilon from neuronal cell bodies to the axons by the action of the microtubule-dependent directed motor protein kinesin-1, also known as KIF5A. Decreased expression of DISC1 in neurons caused an accelerated rate of neuronal integration, resulting in aberrant morphological development, suggesting that DISC1 plays a role in dendritic development and synapse formation.
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分子量
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Predicted: 72, 92, 94 kDa
Observed: 94 kDa -
基因ID
- 27185
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NCBI登录号
- NP_061132
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UniProt
- Q9NRI5
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途径
- Regulation of Cell Size
抗原
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