Carabin 抗体 (C-Term)
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北京 101111
Quick Overview for Carabin 抗体 (C-Term) (ABIN6990767)
抗原
See all Carabin (TBC1D10C) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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纯化方法
- Carabin Antibody is affinity chromatography purified via peptide column.
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免疫原
- Carabin antibody was raised against a 16 amino acid synthetic peptide from near the carboxy terminus of human Carabin. The immunogen is located within the last 50 amino acids of Carabin.
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亚型
- IgG
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anti-TBC1 Domain Family, Member 10C (TBC1D10C) (Internal Region) antibody
Verified TBC1D10C 适用: 人, 小鼠 WB, ELISA, FACS 宿主: 山羊 Polyclonal unconjugated
anti-TBC1 Domain Family, Member 10C (TBC1D10C) (N-Term) antibodyTBC1D10C 适用: 人, Cow, 大鼠, 犬, 豚鼠, 马, 猴, 兔 WB 宿主: 兔 Polyclonal unconjugated
anti-TBC1 Domain Family, Member 10C (TBC1D10C) (N-Term) antibodyTBC1D10C 适用: 人, Cow, 大鼠, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-TBC1 Domain Family, Member 10C (TBC1D10C) (AA 14-236) antibodyTBC1D10C 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-TBC1 Domain Family, Member 10C (TBC1D10C) (C-Term) antibodyTBC1D10C 适用: 人, 小鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
anti-TBC1 Domain Family, Member 10C (TBC1D10C) (N-Term) antibodyTBC1D10C 适用: 人, 小鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
anti-TBC1 Domain Family, Member 10C (TBC1D10C) (N-Term) antibodyTBC1D10C 适用: 人, Cow, 大鼠, 犬, 豚鼠, 马, Pig WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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Carabin antibody can be used for detection of Carabin by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μ,g/mL.
Antibody validated: Western Blot in human samples and Immunohistochemistry in human samples. All other applications and species not yet tested. -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Carabin Antibody is supplied in PBS containing 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,4 °C
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储存方法
- Carabin antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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- Carabin (TBC1D10C) (TBC1 Domain Family, Member 10C (TBC1D10C))
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别名
- Carabin
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背景
- Carabin Antibody: Antigen binding by the T-cell receptor (TCR) is one of the critical first steps in the immune response, triggering a cascade of signaling pathways that ultimately lead to T-cell activation. Screening a yeast two-hybrid screen of a human T-cell cDNA library with calcineurin, a protein phosphatase involved in multiple signaling pathways including T-cell activation, resulted in the identification of Carabin, a member of the TBC1 domain family of proteins, as a calcineurin-binding protein. Unlike other members of the TBC1 domain protein family which are thought to have a role in regulating cell growth and differentiation, further experiments demonstrated that Carabin is part of a negative regulatory loop for the intracellular TCR signaling pathway as well as an inhibitor of the Ras signaling pathway, suggesting that Carabin may also mediate crosstalk between calcineurin and Ras. Carabin antibody does not recognize TBC1D10A or TBC1D10B. Carabin is known to exist in multiple isoforms.
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基因ID
- 374403
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NCBI登录号
- NP_940919
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UniProt
- Q8IV04
抗原
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