At least two isoforms of TSLP-R are known to exist, this antibody will recognize both isoforms.
纯化方法
TSLP Receptor Antibody is affinity chromatography purified via peptide column.
免疫原
TSLP Receptor antibody was raised against a 19 amino acid synthetic peptide from near the center of human TSLP receptor. The immunogen is located within amino acids 140 - 190 of TSLP Receptor.
CRLF2
适用: 小鼠, 大鼠
WB, ELISA, IF (p), IF (cc), IHC (p), IHC (fro)
宿主: 兔
Polyclonal
unconjugated
应用备注
TSLP-R antibody can be used for detection of TSLP-R by Western blot at 0.5 - 1 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.
Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
限制
仅限研究用
状态
Liquid
浓度
1 mg/mL
缓冲液
TSLP Receptor Antibody is supplied in PBS containing 0.02 % sodium azide.
储存液
Sodium azide
注意事项
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
储存条件
-20 °C,4 °C
储存方法
TSLP Receptor antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
抗原
CRLF2
(Cytokine Receptor-Like Factor 2 (CRLF2))
别名
TSLP Receptor
背景
TSLP Receptor Antibody: Thymic stromal lymphopoietin (TSLP) has recently been identified as an important factor capable of driving dendritic cell maturation and activation. It is involved in the positive selection of regulatory T cells, maintenance of peripheral CD4+ T cell homeostasis and the induction of CD4+ T cell-mediated allergic reaction. TSLP is also capable of supporting the growth of fetal liver and adult B cell progenitors and their differentiation to the IgM-positive stage of B cell development. Its receptor TSLP-R will bind TSLP in a low-affinity fashion in transfected cells, co-transfection with IL-7R-alpha cDNA results in high-affinity binding and a functional heteromeric complex. This heteromeric receptor requires stat5 for TSLP-mediated signal transduction and is inhibited by SOCS-1.