CRLF2 抗体 (AA 140-190)
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Quick Overview for CRLF2 抗体 (AA 140-190) (ABIN6990749)
抗原
See all CRLF2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 140-190
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特异性
- At least two isoforms of TSLP-R are known to exist, this antibody will recognize both isoforms.
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纯化方法
- TSLP Receptor Antibody is affinity chromatography purified via peptide column.
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免疫原
- TSLP Receptor antibody was raised against a 19 amino acid synthetic peptide from near the center of human TSLP receptor. The immunogen is located within amino acids 140 - 190 of TSLP Receptor.
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亚型
- IgG
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应用备注
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TSLP-R antibody can be used for detection of TSLP-R by Western blot at 0.5 - 1 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.
Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- TSLP Receptor Antibody is supplied in PBS containing 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,4 °C
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储存方法
- TSLP Receptor antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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- CRLF2 (Cytokine Receptor-Like Factor 2 (CRLF2))
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别名
- TSLP Receptor
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背景
- TSLP Receptor Antibody: Thymic stromal lymphopoietin (TSLP) has recently been identified as an important factor capable of driving dendritic cell maturation and activation. It is involved in the positive selection of regulatory T cells, maintenance of peripheral CD4+ T cell homeostasis and the induction of CD4+ T cell-mediated allergic reaction. TSLP is also capable of supporting the growth of fetal liver and adult B cell progenitors and their differentiation to the IgM-positive stage of B cell development. Its receptor TSLP-R will bind TSLP in a low-affinity fashion in transfected cells, co-transfection with IL-7R-alpha cDNA results in high-affinity binding and a functional heteromeric complex. This heteromeric receptor requires stat5 for TSLP-mediated signal transduction and is inhibited by SOCS-1.
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分子量
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Predicted: 28, 41 kDa
Observed: 53 kDa -
基因ID
- 57914
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NCBI登录号
- NP_071431
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UniProt
- Q8CII9
抗原
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