TMED10 抗体 (AA 70-120)
Quick Overview for TMED10 抗体 (AA 70-120) (ABIN6990698)
抗原
See all TMED10 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 70-120
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纯化方法
- TMP21 Antibody is affinity chromatography purified via peptide column.
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免疫原
- TMP21 antibody was raised against a 18 amino acid synthetic peptide from near the center of human TMP21. The immunogen is located within amino acids 70 - 120 of TMP21.
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亚型
- IgG
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anti-Transmembrane Emp24-Like Trafficking Protein 10 (TMED10) (AA 101-200) antibody
TMED10 适用: 人, 小鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro), ICC 宿主: 兔 Polyclonal unconjugated
anti-Transmembrane Emp24-Like Trafficking Protein 10 (TMED10) (C-Term) antibodyVerified TMED10 适用: 人 ELISA, IF, FACS 宿主: 山羊 Polyclonal unconjugated
anti-Transmembrane Emp24-Like Trafficking Protein 10 (TMED10) (AA 143-192) antibodyTMED10 适用: 人, 小鼠, 大鼠, 兔, Cow, 犬, 马, 斑马鱼, 豚鼠, 小鸡, Hamster, 猴, Pig, 非洲爪蟾 WB 宿主: 兔 Polyclonal unconjugated
anti-Transmembrane Emp24-Like Trafficking Protein 10 (TMED10) (AA 100-200) antibodyTMED10 适用: 人, 小鼠, 大鼠, 兔 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Transmembrane Emp24-Like Trafficking Protein 10 (TMED10) (Center) antibodyTMED10 适用: 人, 小鼠, 大鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
anti-Transmembrane Emp24-Like Trafficking Protein 10 (TMED10) (C-Term) antibodyTMED10 适用: 人, 小鼠, 大鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
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TMP21 antibody can be used for detection of TMP21 by Western blot at 0.5 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL.
Antibody validated: Western Blot in mouse samples and Immunohistochemistry in human samples. All other applications and species not yet tested. -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- TMP21 Antibody is supplied in PBS containing 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,4 °C
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储存方法
- TMP21 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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- TMED10 (Transmembrane Emp24-Like Trafficking Protein 10 (TMED10))
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别名
- TMP21
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背景
- TMP21 Antibody: TMP21 is a ubiquitously expressed protein that is involved in vesicular targeting and protein transport. More recent experiments have shown that it is also a component in the presenilin complex and modulates the gamma-secretase but not the epsilon-secretase cleavage activity of the amyloid precursor protein. The presenilin complex is composed of the proteins APH1, nicastrin, and PEN2 in addition to presenilin-1. Together, these proteins cleave the amyloid precursor protein at what is known as the gamma- and epsilon-sites and can lead to the accumulation of the Abeta cleavage product that is associated with Alzheimer's disease. Co-immunoprecipitation experiments using antibodies against these proteins also yielded TMP21 indicating that TMP21 may play a role in the regulation of this complex. Suppression of TMP21 expression by siRNA in transfected cells caused increased gamma-secretase activity but not epsilon-secretase activity, and increased Abeta, production, demonstrating that TMP21 can modulate gamma-secretase activity.
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基因ID
- 10972
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UniProt
- P49755
抗原
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