Cyclin O 抗体 (AA 90-140)
Quick Overview for Cyclin O 抗体 (AA 90-140) (ABIN6990652)
抗原
See all Cyclin O (CCNO) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 90-140
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特异性
- At least two isoforms of Cyclin O are known to exist, this antibody will recognize both isoforms.
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纯化方法
- Cyclin O Antibody is affinity chromatography purified via peptide column.
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免疫原
- Cyclin O antibody was raised against a 13 amino acid synthetic peptide from near the center of human Cyclin O. The immunogen is located within amino acids 90 - 140 of Cyclin O.
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亚型
- IgG
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anti-Cyclin O (CCNO) (AA 1-257) antibody
CCNO 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Cyclin O (CCNO) (AA 1-350) antibodyCCNO 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Cyclin O (CCNO) antibodyCCNO 适用: 人, 小鼠, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
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Cyclin O antibody can be used for the detection of Cyclin O by Western blot at 1 - 2 μ,g/mL.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested. -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Cyclin O Antibody is supplied in PBS containing 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,4 °C
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储存方法
- Cyclin O antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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- Cyclin O (CCNO)
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别名
- Cyclin O
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背景
- Cyclin O Antibody: Cyclin O, also known as CCNO, has recently been identified as a Cdk1- and Cdk2-activating cyclin specific to apoptosis in lymphoid cells. Cyclin O binds to and activates Cdk2 in response to instrinsic apoptotic stimuli such as glucocorticoids or DNA-damaging agents. Supression of Cyclin O expression by shRNA leads to the inhibition of glucocorticoid and DNA-damage-induced apoptosis due to a failure of apical caspase activation while leaving the CD95 death receptor-mediated apoptosis intact. Note: this gene, which had a previous symbol of UNG2, was erroneously identified as a uracil DNA glycosylase. A later publication identified this gene's product as a cyclin protein family member.
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分子量
- 39 kDa
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基因ID
- 10309
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NCBI登录号
- NP_066970
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UniProt
- P22674
抗原
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