Ectodysplasin A2 Receptor 抗体
Quick Overview for Ectodysplasin A2 Receptor 抗体 (ABIN6990649)
抗原
See all Ectodysplasin A2 Receptor (EDA2R) 抗体适用
宿主
克隆类型
标记
应用范围
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纯化方法
- XEDAR Antibody is affinity chromatography purified via peptide column.
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免疫原
- XEDAR antibody was raised against recombinant human XEDAR.
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亚型
- IgG
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anti-Ectodysplasin A2 Receptor (EDA2R) (AA 1-138) antibody
EDA2R 适用: 人 ELISA, FACS 宿主: 小鼠 Monoclonal 4A6B4 unconjugated
anti-Ectodysplasin A2 Receptor (EDA2R) (AA 1-138) antibodyEDA2R 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Ectodysplasin A2 Receptor (EDA2R) (AA 1-297) antibodyEDA2R 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Ectodysplasin A2 Receptor (EDA2R) (AA 1-110) antibodyEDA2R 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3C1 unconjugated
anti-Ectodysplasin A2 Receptor (EDA2R) (AA 1-297) antibodyEDA2R 适用: 人 WB, FACS 宿主: 小鼠 Polyclonal unconjugated
anti-Ectodysplasin A2 Receptor (EDA2R) (AA 51-150) antibodyEDA2R 适用: 人, 小鼠 ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Ectodysplasin A2 Receptor (EDA2R) (AA 2-135) antibodyEDA2R 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2A10 unconjugated
anti-Ectodysplasin A2 Receptor (EDA2R) antibodyEDA2R 适用: 人 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
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XEDAR antibody can be used for the detection of XEDAR by Western blot at 0.5 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 10 μ,g/mL.
Antibody validated: Western Blot in human samples and Immunohistochemistry in human samples. All other applications and species not yet tested. -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- XEDAR Antibody is supplied in PBS containing 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,4 °C
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储存方法
- XEDAR antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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- Ectodysplasin A2 Receptor (EDA2R)
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别名
- XEDAR
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背景
- XEDAR Antibody: X-linked ectodysplasin-A2 receptor (XEDAR) is a recently isolated member of the tumor necrosis factor receptor family that is highly expressed during embryonic development and binds to ectodysplatin-A2 (EDA-A2). Two predominantly expressed isoforms, XEDAR-s and XEDAR-L, differ by only a 21-amino region at the juxtamembrane region of the cytoplasmic domain. Neither isoform possesses a death domain and both have been shown to act mainly through TRAF3 and TRAF6 to activate the NF-κ,B and JNK pathways. Cells transfected with XEDAR and treated with EDA-A2 cause the assembly of a secondary complex containing FADD, caspase-8 and caspase-10, leading to the activation caspase-8 and caspase-3, and finally apoptosis. The EDA-A2-induced apoptosis is dependent on caspase-9 activation, as various pharmacological and genetic inhibitors of caspase-8 blocked apoptosis following EDA-A2 treatment.
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基因ID
- 60401
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UniProt
- Q9HAV5
抗原
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