Anthrax Edema Factor 抗体 (C-Term)
适用: Bacillus anthracis
ELISA
宿主: 兔
Polyclonal
unconjugated
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- 抗原 See all Anthrax Edema Factor products
- Anthrax Edema Factor
- 抗原表位
- C-Term
- 适用
- Bacillus anthracis
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This Anthrax Edema Factor antibody is un-conjugated
- 应用范围
- ELISA
- 纯化方法
- Anthrax Edema Factor Antibody is affinity chromatography purified via peptide column.
- 免疫原
- Anthrax Edema Factor antibody was raised against a synthetic peptide corresponding to 16 amino acids near the carboxy terminus of the Anthrax edema factor protein. The immunogen is located within the last 50 amino acids of Anthrax Edema Factor.
- 亚型
- IgG
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- 应用备注
- Anthrax Edema Factor antibody can be used for the detection of Anthrax PA protein in ELISA. It will detect 10 ng of free peptide at 1 μ,g/mL.
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Anthrax Edema Factor Antibody is supplied in PBS containing 0.02 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C,4 °C
- 储存方法
- Anthrax Edema Factor antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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- 抗原
- Anthrax Edema Factor
- Abstract
- Anthrax Edema Factor 产品
- 背景
- Anthrax Edema Factor Antibody: Anthrax infection is initiated by the inhalation, ingestion, or cutaneous contact with Bacillus anthracis endospores. B. anthracis produces three polypeptides that comprise the anthrax toxin: protective antigen (PA), lethal factor (LF), and edema factor (EF). PA binds to two related proteins on the cell surface, these are termed tumor epithelial marker 8 (TEM8)/anthrax toxin receptor (ATR) and capillary morphogenesis protein 2 (CMG2), although it is still unclear which is physiologically relevant. Following PA binding to its receptor, PA is cleaved into two fragments by a furin-like protease. The bound fragment binds both LF and EF, the resulting complex is then endocytosed which allows the translocation of LF and EF into the cytoplasm. EF is a calmodulin and Ca++-dependent adenylate cyclase responsible for the edema seen in the disease. It is thought to benefit the B. anthracis bacteria by inhibiting cells of the host immune system.
- 基因ID
- 3361726
- UniProt
- P40136
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