PHAP I 抗体 (C-Term)
This 兔 多克隆 antibody specifically detects PHAP I in WB, ELISA, IF 和 IHC (p). It exhibits reactivity toward 人, 小鼠 和 大鼠.
产品编号 ABIN6990427
发货至:
中国
Contact our Customer Service for availability and price in your country.
Contact Info
Our Local Distributor
中国
北京 101111
北京 101111
No. 88 KeChuang 6th Street
Beijing Economic Technological Development Area
Room 801-803
Quick Overview for PHAP I 抗体 (C-Term) (ABIN6990427)
抗原
PHAP I
适用
人, 小鼠, 大鼠
宿主
兔
克隆类型
多克隆
标记
This PHAP I antibody is un-conjugated
应用范围
Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
-
-
抗原表位
- C-Term
-
特异性
- This polyclonal antibody has no cross-reaction to PHAP I2a and PHAP III.
-
纯化方法
- PHAP I Antibody is affinity chromatography purified via peptide column.
-
免疫原
- Anti-PHAP I antibody was raised against a peptide corresponding to 14 amino acids near the carboxy terminus of human PHAP I . The immunogen is located within the last 50 amino acids of PHAP I.
-
亚型
- IgG
-
-
-
-
应用备注
-
WB: 1 μ,g/mL, IHC: 2 μ,g/mL, IF: 20 μ,g/mL.
Antibody validated: Western Blot in human, mouse and rat samples, Immunohistochemistry in mouse samples, Immunofluorescence in mouse samples. All other applications and species not yet tested. -
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
浓度
- 1 mg/mL
-
缓冲液
- PHAP I Antibody is supplied in PBS containing 0.02 % sodium azide.
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C,4 °C
-
储存方法
- PHAP I antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
-
-
- PHAP I
-
背景
- PHAP I Antibody: Apoptosis is related to many diseases and development. Caspase-9 plays a central role in cell death induced by a variety of apoptosis activators. Cytochrome c, after released from mitochondria, binds to Apaf-1, which forms an apoptosome that in turn binds to and activate procaspase-9. Activated caspase-9 cleaves and activates the effector caspases (caspase-3, -6 and -7), which are responsible for the proteolytic cleavage of many key proteins in apoptosis. The tumor suppressor putative HLA-DR-associated proteins (PHAPs) were recently identified as important regulators of mitochondrion apoptosis. PHAP appears to facilitate apoptosome-medicated caspase-9 activation and to stimulate the mitochondrial apoptotic pathway. PHAP was also shown to oppose both Ras- and Myc-medicated cell transformation.
-
分子量
-
Predicted: 29kD
Observed: 29 kD kDa -
基因ID
- 8125
-
UniProt
- P39687
抗原
-
You are here:
