PAK6 抗体 (AA 260-310)
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北京 101111
Quick Overview for PAK6 抗体 (AA 260-310) (ABIN6990412)
抗原
See all PAK6 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 260-310
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特异性
- PAK6 antibody is predicted to not cross-react with other PAK family proteins.
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纯化方法
- PAK6 Antibody is affinity chromatography purified via peptide column.
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免疫原
- PAK6 antibody was raised against a 13 amino acid synthetic peptide from near the center of human PAK6. The immunogen is located within amino acids 260 - 310 of PAK6.
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亚型
- IgG
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应用备注
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PAK6 antibody can be used for the detection of PAK6 by Western blot at 1 - 4 μ,g/mL. Antibody can also be used for immunocytochemistry starting at 10 μ,g/mL. For immunofluorescence start at 10 μ,g/mL.
Antibody validated: Western Blot in human samples, Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- PAK6 Antibody is supplied in PBS containing 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,4 °C
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储存方法
- PAK6 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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- PAK6 (P21-Activated Kinase 6 (PAK6))
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别名
- PAK6
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背景
- PAK6 Antibody: The p21-activated kinases (PAKs) are serine-threonine kinases that bind to the active forms of Cdc42 and Rac. They are divided into two groups, the first of which include PAK1, 2 and 3, and can be activated by Cdc42/Rac binding. Group 1 PAKs contain an autoinhibitory domain whose activity is regulated by Cdc42/Rac binding. The group 1 PAKs are known to be involved in cellular processes such as gene transcription, apoptosis, and cell morphology and motility. Much less is known about the second group, which includes PAK4, 5 and 6. These proteins are not activated by Cdc42/Rac binding. PAK6 was initially identified as an androgen receptor in a yeast two hybrid screen and was found to be highly expressed in testis and prostate tissues. Later experiments have shown it to be activated by MAP kinase kinase 6 and p38 MAP kinase, suggesting that PAK6 may play a role in the cellular response to stress-related signals.
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分子量
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Predicted: 75 kDa
Observed: 70 kDa -
基因ID
- 56924
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NCBI登录号
- NP_064553
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UniProt
- Q9NQU5
抗原
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