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CXCR4 抗体 (AA 170-220)

Name: CXCR4 抗体 (AA 170-220)
Brand: antibodies-online
SKU: ABIN6990403
Availability: OutOfStock

This anti-CXCR4 antibody is a 兔多克隆 antibody detecting CXCR4 in WB, ELISA, IHC 和 IF. Suitable for 人, 小鼠和大鼠.

产品编号 ABIN6990403

发货至: 中国

Quick Overview for CXCR4 抗体 (AA 170-220) (ABIN6990403)

抗原

See all CXCR4 抗体

CXCR4 (Chemokine (C-X-C Motif) Receptor 4 (CXCR4))

适用

人, 小鼠, 大鼠

宿主

兔

克隆类型

多克隆

标记

This CXCR4 antibody is un-conjugated

应用范围

Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Discover our top product CXCR4 Primary Antibody

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AA 170-220

纯化方法

CXCR4 Antibody is Antibody is affinity chromatography purified via peptide column.

免疫原

Anti-CXCR4 antibody was raised against a peptide corresponding to 15 amino acids near the center of human CXCR4 isoform b. The immunogen is located within amino acids 170-220 of CXCR4.

亚型

IgG
anti-Chemokine (C-X-C Motif) Receptor 4 (CXCR4) (AA 201-294) antibody
CXCR4 适用: 人, 小鼠, 大鼠, 兔 WB, ELISA, FACS, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Chemokine (C-X-C Motif) Receptor 4 (CXCR4) (AA 1-46) antibody
CXCR4 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2G9 unconjugated

anti-Chemokine (C-X-C Motif) Receptor 4 (CXCR4) (AA 262-352) antibody
CXCR4 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Chemokine (C-X-C Motif) Receptor 4 (CXCR4) (N-Term) antibody
CXCR4 适用: 人, 小鼠, 兔, Pig, 马 WB, IHC, FACS 宿主: 兔 Polyclonal unconjugated

anti-Chemokine (C-X-C Motif) Receptor 4 (CXCR4) (AA 14-40) antibody
CXCR4 适用: 人, 小鼠 WB, ELISA, IHC, IHC (p) 宿主: 山羊 Polyclonal unconjugated

anti-Chemokine (C-X-C Motif) Receptor 4 (CXCR4) (AA 1-356) antibody
CXCR4 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Chemokine (C-X-C Motif) Receptor 4 (CXCR4) (C-Term) antibody
CXCR4 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Chemokine (C-X-C Motif) Receptor 4 (CXCR4) (AA 1-46) antibody
CXCR4 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1F8 unconjugated

anti-Chemokine (C-X-C Motif) Receptor 4 (CXCR4) antibody (PE)
CXCR4 适用: 人, Non-Human Primate FACS 宿主: 小鼠 Monoclonal 12G5 PE

anti-Chemokine (C-X-C Motif) Receptor 4 (CXCR4) (AA 2-15), (Extracellular) antibody
CXCR4 适用: 人 WB, IHC, FACS, IF, IC, LCI 宿主: 兔 Polyclonal unconjugated

应用备注

WB: 1 - 2 μ,g/mL, IHC-P: 5 μ,g/mL, IF: 4 μ,g/mL.

Antibody validated: Western Blot in human, mouse, and rat samples, Immunohistochemistry and Immunofluorescence in human samples. All other applications and species not yet tested.

限制

仅限研究用
状态

Liquid

浓度

1 mg/mL

缓冲液

CXCR4 Antibody is supplied in PBS containing 0.02 % sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

-20 °C,4 °C

储存方法

CXCR4 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
抗原

CXCR4 (Chemokine (C-X-C Motif) Receptor 4 (CXCR4))

别名

CXCR4

背景

CXCR4, a G-protein coupled receptor (GPCR) with seven transmembrane domains, is a CXC chemokine receptor specific for stromal-derived-factor-1 (SDF-1 or CXCL12). CXCR4 was initially discovered as one of the co-receptors for HIV entry into CD4+ T cells (1). Blocking CXCR4 could be potentially used as novel therapeutics for HIV treatment.

CXCR4 signaling plays an important role in the migration, proliferation and quiescence of hematopoietic stem cell and their retention within the bone marrow, where it has high levels of SDF-1/CXCL12(2). It has been demonstrated that CXCR4 signaling mediates CD20 up-regulation on B cells (3).

CXCR4 is highly expressed in more than 23 types of cancer, including breast cancer, ovarian cancer, melanoma, and prostate cancer, while there is very less or no expression of CXCR4 in healthy tissues. CXCR4 expression in cancer cells has been reported to be associated with tumor survival, growth and metastasis in tissues with high levels of SDF-1/CXCL12, such as lungs, liver and bone marrow (4,5).

CXCR4 has been shown to regulate neuronal migration, cell positioning and axon wiring (6,7). CXCR4 mutant mice displayed aberrant neuronal distribution, which implicates the role in neuronal disorders such as epilepsy. CXCR4 is also involved in WHIM syndrome (8). WHIM mutations in CXCR4 were recently found in patients with Waldenstrom's macroglobulinemia, and these mutations are correlated to clinical resistance to ibrutinib (9,10).

分子量

Predicted: 40kD

Observed: 44kD (Post-modification: 2 N-linked glycosylation) kDa

基因ID

7852

NCBI登录号

NP_003458

UniProt

P61073

途径

Regulation of Cell Size, CXCR4-mediated Signaling Events