NOD2 抗体 (N-Term)
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北京 101111
Quick Overview for NOD2 抗体 (N-Term) (ABIN6990388)
抗原
See all NOD2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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特异性
- At least four isoforms of NOD2 are known to exist, this antibody will only detect the longest isoform. NOD2 has no cross-reaction with NOD1.
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纯化方法
- NOD2 Antibody is immunoaffinity chromatography purified IgG.
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免疫原
- NOD2 antibody was raised against a synthetic peptide corresponding to 16 amino acids at the amino terminus of human NOD2. The immunogen is located within the first 50 amino acids of NOD2.
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亚型
- IgG
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anti-Nucleotide-Binding Oligomerization Domain Containing 2 (NOD2) (N-Term) antibody
NOD2 适用: 人, 小鼠, 大鼠 WB, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Nucleotide-Binding Oligomerization Domain Containing 2 (NOD2) (AA 251-350) antibodyNOD2 适用: 人 ELISA, WB, FACS 宿主: 兔 Polyclonal unconjugated
anti-Nucleotide-Binding Oligomerization Domain Containing 2 (NOD2) (AA 460-733) antibodyNOD2 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Nucleotide-Binding Oligomerization Domain Containing 2 (NOD2) antibodyNOD2 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Nucleotide-Binding Oligomerization Domain Containing 2 (NOD2) (AA 1-1040) antibodyNOD2 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Nucleotide-Binding Oligomerization Domain Containing 2 (NOD2) (C-Term) antibodyNOD2 适用: 人 ELISA, WB, IHC, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Nucleotide-Binding Oligomerization Domain Containing 2 (NOD2) (AA 251-350) antibody (AbBy Fluor® 488)NOD2 适用: 人 WB, FACS 宿主: 兔 Polyclonal AbBy Fluor® 488
anti-Nucleotide-Binding Oligomerization Domain Containing 2 (NOD2) (Internal Region) antibodyVerified NOD2 适用: 人 ELISA, WB 宿主: 山羊 Polyclonal unconjugated
anti-Nucleotide-Binding Oligomerization Domain Containing 2 (NOD2) (AA 1-1040) antibodyNOD2 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Nucleotide-Binding Oligomerization Domain Containing 2 (NOD2) antibodyNOD2 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
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应用备注
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NOD2 antibody can be used for detection of NOD2 by Western blot at 1 to 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 10 μ,g/mL.
Antibody validated: Western Blot in human samples, Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- NOD2 Antibody is supplied in PBS containing 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,4 °C
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储存方法
- NOD2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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- NOD2 (Nucleotide-Binding Oligomerization Domain Containing 2 (NOD2))
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别名
- NOD2
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背景
- NOD2 Antibody: Apaf-1 and NOD1 are members of a new family, which are involved in the regulation of apoptosis and immune response. Each of them contains a caspase recruitment domain (CARD) and a nucleotide-binding oligomerization domain (NOD). A third member in this family was recently identified and designated NOD2. NOD2 interacts with RICK via a homophilic CARD-CARD interaction. NOD2 activates NF-κ,B, which is regulated by its carboxy-terminal leucine-rich repeat domain that acts as an intracellular receptor for components of bacteria. The variants of NOD2, either a frameshift or a missense, were associated with Crohn's disease that is a main type of chronic inflammatory bowel disease.
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分子量
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Predicted: 114 kDa
Observed: 100 kDa -
基因ID
- 64127
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UniProt
- Q9HC29
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途径
- Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Toll-Like Receptors Cascades, Inflammasome
抗原
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