TRAF3IP2 抗体 (N-Term)
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北京 101111
Quick Overview for TRAF3IP2 抗体 (N-Term) (ABIN6990385)
抗原
See all TRAF3IP2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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纯化方法
- CIKS Antibody is affinity chromatography purified via peptide column.
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免疫原
- CIKS antibody was raised against a 14 amino acid peptide near the amino terminus of human CIKS. The immunogen is located within the first 50 amino acids of CIKS.
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亚型
- IgG
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应用备注
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CIKS antibody can be used for detection of CIKS by Western blot at 1 μ,g/mL. A band at approximately 63 kDa can be detected. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.
Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- CIKS Antibody is supplied in PBS containing 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,4 °C
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储存方法
- CIKS antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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- TRAF3IP2 (TRAF3 Interacting Protein 2 (TRAF3IP2))
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别名
- CIKS
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背景
- CIKS Antibody: Nuclear factor kappa B (NF-κ,B) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-κ,B mediates the expression of a great variety of genes in response to extracellular stimuli. NF-κ,B associates with Iκ,B proteins in the cell cytoplasm, which inhibit NF-κ,B activity. Iκ,B is phosphorylated by Iκ,B kinase (IKK) complex that contains IKKα, IKKβ, and IKKγ,. A novel molecule that associates with and activates IKK was recently identified and designated CIKS (for connection to IKK and SAPK/JNK) and Act1 (for NF-κ,B activator 1). CIKS directly interacts with IKKγ,. CIKS/Act1 also activates activating transcription factor (ATF) and activator protein 1 (AP-1) through Jun kinase (JNK). These results indicate that CIKS/Act1 is involved in the inflammation and stress responses. CIKS/Act1 is ubiquitously expressed in human tissues.
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分子量
- 63 kDa
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基因ID
- 10758
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UniProt
- O43734
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途径
- Production of Molecular Mediator of Immune Response
抗原
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