KappaB Ras (AA 80-130) 抗体
适用: 人, 小鼠, 大鼠
ELISA, WB, IHC (p)
宿主: 兔
Polyclonal
unconjugated
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- 抗原
- KappaB Ras
- 抗原表位
- AA 80-130
- 适用
- 人, 小鼠, 大鼠
- 宿主
- 兔
- 克隆类型
- 多克隆
- 应用范围
- ELISA, Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- 纯化方法
- KappaB ras Antibody is affinity chromatography purified via peptide column.
- 免疫原
- KappaB ras antibody was raised against a 18 amino acid synthetic peptide from near the center of human KappaB ras 1. The immunogen is located within amino acids 80 - 130 of KappaB ras.
- 亚型
- IgG
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- 应用备注
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KappaB ras antibody can be used for detection of KappaB ras by Western blot at 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 1 μ,g/mL.
Antibody validated: Western Blot in mouse samples and Immunohistochemistry in human samples. All other applications and species not yet tested. - 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- KappaB ras Antibody is supplied in PBS containing 0.02 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C,4 °C
- 储存方法
- KappaB ras antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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- 抗原
- KappaB Ras
- 背景
- KappaB ras Antibody: KappaB ras-1 (κ,B-ras-1) and kappaB-ras-2 are two small proteins that similar to Ras-like small GTPases that associate with Iκ,B (Iκ,B), an inhibitor of the transcription factor NF-κ,B. Iκ,B exists in two homologous forms, Iκ,B-alpha and Iκ,B-beta, although Iκ,B-beta contains a unique 47-amino acid region within its ankyrin domain. While inactive Iκ,B-alpha-NF-κ,B complexes can shuttle in and out of the nucleus, Iκ,B-beta-NF-κ,B complexes are retained exclusively in the cytoplasm. It is suggested that kappaB-ras proteins preferentially bind to the Iκ,B-beta form through this unique insert within the ankyrin region, thus modulating the cellular location of Iκ,B-beta and regulating the rate of degradation of Iκ,B-beta. This antibody detects both kappaB-ras1 and kappaB-ras2.
- 基因ID
- 28512
- UniProt
- Q9NYS0
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