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IL-33 抗体 (AA 150-200)

This anti-IL-33 antibody is a 兔 多克隆 antibody detecting IL-33 in WB, ELISA, IF 和 IHC (p). Suitable for 人 和 小鼠.
产品编号 ABIN6990277
发货至: 中国

Quick Overview for IL-33 抗体 (AA 150-200) (ABIN6990277)

抗原

See all IL-33 (IL33) 抗体
IL-33 (IL33) (Interleukin 33 (IL33))

适用

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人, 小鼠

宿主

  • 107
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克隆类型

  • 113
  • 42
多克隆

标记

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This IL-33 antibody is un-conjugated

应用范围

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Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
  • 抗原表位

    • 18
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    AA 150-200

    纯化方法

    IL-33 Antibody is affinity chromatography purified via peptide column.

    免疫原

    Anti-IL-33 antibody was raised against a 17 amino acid synthetic peptide from near the center of human IL-33. The immunogen is located within the 150-200 amino acids of IL-33.

    亚型

    IgG
  • 应用备注

    WB: 1-2 μ,g/mL, IF: 20 μ,g/mL, IHC-P: 2.5 μ,g/mL.

    Antibody validated: Western Blot in human and mouse samples, Immunofluorescence and Immunohistochemistry in human samples. All other applications and species not yet tested.

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    1 mg/mL

    缓冲液

    IL-33 Antibody is supplied in PBS containing 0.02 % sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C,4 °C

    储存方法

    IL-33 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • 抗原

    IL-33 (IL33) (Interleukin 33 (IL33))

    别名

    IL-33

    背景

    IL-33 Antibody: Interleukin-33 (IL-33) is a recently identified member of the IL-1 family of cytokines whose other members include IL-1α,/beta, IL-1Ra and IL-18. Its receptor has been shown to be ST2, an IL-1 receptor family member that also acts as a negative regulator of TLR-IL-1R signaling and IL-1R accessory protein (IL-1RAcP). Receptor binding of IL-33 activates NF-κ,B and MAP kinases and induces the expression of TH2-associated cytokines such as IL-4, IL-5 and IL-6. Prolonged IL-33 treatment of mice led to the development of eosinophilia, splenomegaly, and severe pathological changes in mucosal organs such as lungs, esophagus and small intestine. Recent experiments have shown that IL-33 can also co-localize with heterochromatin and possesses transcriptional repressor activities, indicating that IL-33 may function as both a proinflammatory cytokine and an intracellular nuclear factor with transcriptional regulatory properties.

    分子量

    Predicted: 31kD

    Observed: 33kD kDa

    基因ID

    90865

    NCBI登录号

    NP_254274

    UniProt

    O95760

    途径

    Production of Molecular Mediator of Immune Response
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