KLF4 抗体 (C-Term)
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北京 101111
Quick Overview for KLF4 抗体 (C-Term) (ABIN6990208)
抗原
See all KLF4 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- C-Term
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特异性
- At least three isoforms of KLF4 are known to exist, this antibody will detect all three. KLF4 antibody will not cross-react with other Kruppel-like family members.
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纯化方法
- KLF4 Monoclonal Antibody is affinity chromatography purified via peptide column.
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免疫原
- KLF4 antibody was raised against a 20 amino acid synthetic peptide near the carboxy terminus of human KLF4.
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亚型
- IgG1
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应用备注
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KLF4 antibody can be used for detection of KLF4 by Western blot at 1 μ,g/mL.
Antibody validated: Western Blot in mouse samples. All other applications and species not yet tested. -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- KLF4 Monoclonal Antibody is supplied in PBS containing 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- KLF4 monoclonal antibody can be stored at -20°C, stable for one year.
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- KLF4 (Kruppel-Like Factor 4 (Gut) (KLF4))
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别名
- KLF4
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背景
- KLF4 Monoclonal Antibody: KLF4 is a transcription factor that functions as both a transcriptional activator and repressor to regulate proliferation and differentiation of multiple cell types. The role of KLF4 in embryonic development suggested that it might be useful in the creation of stem cells that might be useful in cell replacement therapies in the treatment of several degenerative diseases. Artificial stem cells, termed induced pluripotent stem (iPS) cells, can be created by expressing KLF4 and the transcription factors POU5F1, Sox2, and Lin28 along with c-Myc in mouse fibroblasts. More recently, experiments have demonstrated that iPS cells could be generated using expression plasmids expressing KLF4, Sox2, POU5F1 and c-Myc, eliminating the need for virus introduction, thereby addressing a safety concern for potential use of iPS cells in regenerative medicine. KLF4 interacts directly with POU5F1 and Sox2 in iPS and ES cells and activates the target gene NANOG.
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基因ID
- 9314
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UniProt
- O43474
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途径
- Peptide Hormone Metabolism, Stem Cell Maintenance
抗原
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