GSK3 alpha/beta 抗体 (pTyr216, pTyr279)
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Quick Overview for GSK3 alpha/beta 抗体 (pTyr216, pTyr279) (ABIN6989926)
抗原
适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- pTyr216, pTyr279
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交叉反应
- 人, 小鼠, 大鼠
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纯化方法
- Purified by Protein A.
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免疫原
- Synthetic phospho-Peptide corresponding to residues surrounding Tyr216 and 279 of human GSK3(alpha+beta).
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亚型
- IgG
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anti-Glycogen Synthase Kinase 3 alpha/beta (GSK3a/b) (pTyr216), (pTyr279) antibody
GSK3a/b 适用: 人, 大鼠, 小鼠 WB, ELISA, FACS, IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Glycogen Synthase Kinase 3 alpha/beta (GSK3a/b) antibodyKD Validated GSK3a/b 适用: 人 WB, FACS 宿主: 兔 Monoclonal 23GB1100 unconjugated Recombinant Antibody
anti-Glycogen Synthase Kinase 3 alpha/beta (GSK3a/b) (Ser4520) antibodyGSK3a/b 适用: 人, 大鼠, 小鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Glycogen Synthase Kinase 3 alpha/beta (GSK3a/b) antibodyGSK3a/b 适用: 人, 大鼠, 小鼠, 非洲爪蟾 WB, IHC, ELISA, IHC (p), IP 宿主: 小鼠 Monoclonal unconjugated
anti-Glycogen Synthase Kinase 3 alpha/beta (GSK3a/b) (AA 246-295), (pTyr279) antibodyGSK3a/b 适用: 人, 大鼠, 小鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Glycogen Synthase Kinase 3 alpha/beta (GSK3a/b) (Center) antibodyGSK3a/b 适用: 人, 大鼠, 小鼠, 斑马鱼 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Glycogen Synthase Kinase 3 alpha/beta (GSK3a/b) (pTyr216), (pTyr279) antibodyGSK3a/b 适用: 人, 大鼠, 小鼠, 斑马鱼 WB, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB 1:300-5000
IHC-P 1:200-400
IF(ICC) 1:50-200
IP(1-2 μg)
IHC() -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
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有效期
- 12 months
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- GSK3 alpha/beta (GSK3a/b) (Glycogen Synthase Kinase 3 alpha/beta (GSK3a/b))
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别名
- GSK3(alpha+beta)
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背景
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Synonyms: Factor A antibody, Glycogen synthase kinase 3 alpha antibody, Glycogen synthase kinase 3 beta antibody, GSK3 alpha antibody, GSK3 beta antibody, GSK3B antibody
Background: Glycogen synthase kinase 3 (GSK3) is a proline directed serine threonine kinase that was initially identified as a phosphorylating and inactivating glycogen synthase, a key enzyme in glycogen metabolism. Since then, it has been shown to be involved in the regulation of a diverse array of cellular functions, including protein synthesis, cell proliferation, cell differentiation, microtubule assembly/disassembly, and apoptosis. GSK3s substrate specificity is unique in that phosphorylation of substrate only occurs if a phosphoserine or phosphotyrosine is present four residues C terminal to the site of GSK phosphorylation. There exists two isoforms of GSK3, alpha and beta, and they show a high degree of amino acid homology. The two isoforms of GSK3 are strictly regulated via phosphorylation. Phosphorylation of GSK3 beta on Ser9 (Ser21 in GSK3 alpha) by protein kinase B (PKB) causes its inactivation is the primary mechanism responsible for growth factor inhibition of this kinase. Activation of GSK3 beta is dependent upon the phosphorylation of Tyr216 (Tyr279 in GSK3 alpha). Upon activation, it has been shown to phosphorylate a number of different cellular proteins, including p53, c-Myc, c-Jun, heat shock factor 1 (HSF1), and cyclin D1. GSK3 beta also has been shown to phosphorylate aberrant sites on the microtubule associated protein tau, which is critical for the progression of Alzheimer's disease. GSK3B is involved in energy metabolism, neuronal cell development, and body pattern formation.
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基因ID
- 2932
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UniProt
- P49840
抗原
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