CHCHD2 抗体
Quick Overview for CHCHD2 抗体 (ABIN6989760)
抗原
适用
宿主
克隆类型
标记
应用范围
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交叉反应
- 人, 小鼠, 大鼠
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纯化方法
- Purified by Protein A.
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免疫原
- Recombinant fusion protein containing a sequence corresponding to amino acids 75-145 of human CHCHD2 (NP_057223.1).
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亚型
- IgG
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anti-Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 2 (CHCHD2) (AA 75-145) antibody
KO Validated CHCHD2 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 2 (CHCHD2) (Internal Region) antibodyCHCHD2 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 2 (CHCHD2) (AA 96-130) antibodyCHCHD2 适用: 小鼠 WB, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 2 (CHCHD2) (AA 74-103) antibodyCHCHD2 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB27708 unconjugated
anti-Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 2 (CHCHD2) (AA 81-111), (Middle Region) antibodyCHCHD2 适用: 人 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB 1:300-5000
IF(ICC) 1:50-200
IF() -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C for 12 months.
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有效期
- 12 months
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- CHCHD2 (Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 2 (CHCHD2))
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别名
- CHCHD2
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背景
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Synonyms: CHCHD2,C7orf17,MNRR1,NS2TP,PARK22
Background: The protein encoded by this gene belongs to a class of eukaryotic CX(9)C proteins characterized by four cysteine residues spaced ten amino acids apart from one another. These residues form disulfide linkages that define a CHCH fold. In response to stress, the protein translocates from the mitochondrial intermembrane space to the nucleus where it binds to a highly conserved 13 nucleotide oxygen responsive element in the promoter of cytochrome oxidase 4I2, a subunit of the terminal enzyme of the electron transport chain. In concert with recombination signal sequence-binding protein J, binding of this protein activates the oxygen responsive element at four percent oxygen. In addition, it has been shown that this protein is a negative regulator of mitochondria-mediated apoptosis. In response to apoptotic stimuli, mitochondrial levels of this protein decrease, allowing BCL2-associated X protein to oligomerize and activate the caspase cascade. Pseudogenes of this gene are found on multiple chromosomes. Alternative splicing results in multiple transcript variants.
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基因ID
- 51142
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UniProt
- Q9Y6H1
抗原
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