TTC3 抗体 (AA 251-350)
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北京 101111
Quick Overview for TTC3 抗体 (AA 251-350) (ABIN6989022)
抗原
See all TTC3 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 251-350
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交叉反应
- 小鼠, 大鼠
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预测反应
- Human
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic peptide derived from human RNF105
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亚型
- IgG
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anti-Tetratricopeptide Repeat Domain 3 (TTC3) (AA 1-110) antibody
TTC3 适用: 人 ELISA, WB 宿主: 小鼠 Polyclonal unconjugated
anti-Tetratricopeptide Repeat Domain 3 (TTC3) (AA 1-110) antibodyTTC3 适用: 人 ELISA 宿主: 小鼠 Monoclonal 2D10 unconjugated
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应用备注
- IHC-P 1:200-400
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
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有效期
- 12 months
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- TTC3 (Tetratricopeptide Repeat Domain 3 (TTC3))
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别名
- RNF105
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背景
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Synonyms: DCRR1, E3 ubiquitin protein ligase TTC3, E3 ubiquitin-protein ligase TTC3, Protein DCRR1, RING finger protein 105,Tetratricopeptide repeat protein 3 (TPR repeat protein D), Tetratricopeptide repeat protein 3, TPR repeat protein 3, TPR repeat protein D, TPRD, TPRDI, TPRDII, TPRDIII, TTC3, TTC3_HUMAN.
Background: E3 ubiquitin-protein ligase that mediates the ubiquitination and subsequent degradation of phosphorylated Akt (AKT1, AKT2 and AKT3) in the nucleus. Acts as a terminal regulator of Akt signaling after activation, its phosphorylation by Akt, which is a prerequisite for ubiquitin ligase activity, suggests the existence of a regulation mechanism required to control Akt levels after activation. Catalyzes the formation of 'Lys-48'-polyubiquitin chains. May play a role in neuronal differentiation inhibition via its interaction with CIT.
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基因ID
- 7267
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UniProt
- P53804
抗原
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