ZAP70 抗体 (pTyr493) (PE)
Quick Overview for ZAP70 抗体 (pTyr493) (PE) (ABIN6988682)
抗原
See all ZAP70 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
 - pTyr493
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预测反应
 - Human,Mouse,Rat,Cow,Pig,Horse,Rabbit
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纯化方法
 - Purified by Protein A.
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免疫原
 - KLH conjugated synthetic phosphopeptide derived from human Zap-70 around the phosphorylation site of Tyr493
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亚型
 - IgG
 
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应用备注
 - FCM 1:20-100
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限制
 - 仅限研究用
 
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状态
 - Liquid
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浓度
 - 1 μg/μL
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缓冲液
 - Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
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储存液
 - ProClin
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注意事项
 - This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
 - -20 °C
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储存方法
 - Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
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有效期
 - 12 months
 
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- ZAP70 (zeta-Chain (TCR) Associated Protein Kinase 70kDa (ZAP70))
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别名
 - ZAP70
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背景
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Synonyms: Zap-70Tyr493, ZAP70 phospho Y493, p-ZAP70 Y292, p-Zap-70Tyr292, p-Zap-70Y292, ZAP-70, ZAP 70, ZAP70, zeta-associated protein 70, ZAP-70=protein tyrosine kinase Syk homolog {SH2-like and C-terminal kinase domains}, Tyrosine-protein kinase ZAP-70, 70 kDa zeta-associated protein, Syk-related tyrosine kinase. SRK, STD, TZK, ZAP70_HUMAN, Tyrosine-protein kinase ZAP-70, 70 kDa zeta-chain associated protein.
Background: This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
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基因ID
 - 7535
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途径
 - TCR Signaling, Ubiquitin Proteasome Pathway
 
抗原
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