SOCS3 抗体 (AA 161-225) (HRP)
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- 抗原 See all SOCS3 抗体
- SOCS3 (Suppressor of Cytokine Signaling 3 (SOCS3))
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抗原表位
- AA 161-225
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适用
- 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This SOCS3 antibody is conjugated to HRP
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应用范围
- Western Blotting (WB)
- 交叉反应
- 小鼠, 大鼠
- 预测反应
- Human,Dog,Cow,Sheep,Pig,Horse,Rabbit
- 纯化方法
- Purified by Protein A.
- 免疫原
- KLH conjugated synthetic peptide derived from human SOCS3
- 亚型
- IgG
- Top Product
- Discover our top product SOCS3 Primary Antibody
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- 应用备注
- WB 1:300-5000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 μg/μL
- 缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- 有效期
- 12 months
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- 抗原
- SOCS3 (Suppressor of Cytokine Signaling 3 (SOCS3))
- 别名
- SOCS3 (SOCS3 产品)
- 别名
- socs3 antibody, fj09e12 antibody, zgc:56537 antibody, wu:fj09e12 antibody, MGC64393 antibody, MGC75749 antibody, xsocs3 antibody, MGC81248 antibody, atod4 antibody, cis3 antibody, cish3 antibody, socs-3 antibody, ssi-3 antibody, ssi3 antibody, SOCS3 antibody, ATOD4 antibody, CIS3 antibody, Cish3 antibody, SOCS-3 antibody, SSI-3 antibody, SSI3 antibody, Cis3 antibody, EF-10 antibody, Ef10 antibody, Ssi3 antibody, Socs-3 antibody, Ssi-3 antibody, suppressor of cytokine signaling 3a antibody, suppressor of cytokine signaling 3 S homeolog antibody, suppressor of cytokine signaling 3 antibody, suppressor of cytokine signaling 3 L homeolog antibody, socs3a antibody, socs3.S antibody, socs3 antibody, socs3.L antibody, SOCS3 antibody, Socs3 antibody
- 背景
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Synonyms: suppressor of cytokine signaling 3, ATOD4, CIS 3, CIS3, Cish3, Cytokine induced SH2 protein 3, E2a Pbx1 target gene in fibroblasts 10, EF 10, MGC71791, SOCS 3, SOCS-3, SSI 3, SSI3, STAT induced STAT inhibitor 3, Suppressor of cytokine signaling 3, SOCS3_HUMAN.
Background: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells. Regulates IL-6 signaling in vivo (By similarity). Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize IL6ST (By similarity).
- 基因ID
- 9021
- UniProt
- O14543
- 途径
- JAK/STAT Signaling, Response to Growth Hormone Stimulus, Hepatitis C
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