TBPL1 抗体 (AA 401-495) (HRP)
Quick Overview for TBPL1 抗体 (AA 401-495) (HRP) (ABIN6987855)
抗原
See all TBPL1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 401-495
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交叉反应
- 大鼠
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预测反应
- Mouse
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic peptide derived from mouse TRF2
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亚型
- IgG
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anti-TBP-Like 1 (TBPL1) (AA 1-186) antibody
TBPL1 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-TBP-Like 1 (TBPL1) (AA 88-137) antibodyTBPL1 适用: 人, 小鼠, 大鼠, 猴, 犬, Cow, 豚鼠, 马, 兔, Bat, 小鸡, Hamster, Pig WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-TBP-Like 1 (TBPL1) (AA 1-186) antibodyTBPL1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-TBP-Like 1 (TBPL1) (AA 301-400) antibodyTBPL1 适用: 人, 小鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-TBP-Like 1 (TBPL1) (AA 1-185) antibodyTBPL1 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-TBP-Like 1 (TBPL1) (C-Term) antibodyVerified TBPL1 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-TBP-Like 1 (TBPL1) (Middle Region) antibodyTBPL1 适用: 人, 小鼠, 大鼠, 犬, Cow, 豚鼠, 马, 兔, 斑马鱼 WB, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:300-5000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
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有效期
- 12 months
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- TBPL1 (TBP-Like 1 (TBPL1))
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别名
- TRF2
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背景
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Synonyms: Telomeric DNA binding protein, Telomeric repeat binding factor 2, Telomeric repeat binding protein 2, TERF 2, TERF2, TRBF 2, TRBF2, TRF 2, TTAGGG repeat binding factor 2.
Background: Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and plays a central role in telomere maintenance and protection against end-to-end fusion of chromosomes. In addition to its telomeric DNA-binding role, required to recruit a number of factors and enzymes required for telomere protection, including the shelterin complex, TERF2IP/RAP1 and DCLRE1B/Apollo. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends, without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Together with DCLRE1B/Apollo, plays a key role in telomeric loop (T loop) formation by generating 3' single-stranded overhang at the leading end telomeres: T loops have been proposed to protect chromosome ends from degradation and repair. Required both to recruit DCLRE1B/Apollo to telomeres and activate the exonuclease activity of DCLRE1B/Apollo. Preferentially binds to positive supercoiled DNA. Together with DCLRE1B/Apollo, required to control the amount of DNA topoisomerase (TOP1, TOP2A and TOP2B) needed for telomere replication during fork passage and prevent aberrant telomere topology. Recruits TERF2IP/RAP1 to telomeres, thereby participating in to repressing homology-directed repair (HDR), which can affect telomere length.
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基因ID
- 7014
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UniProt
- Q15554
抗原
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