PLK4 抗体 (HRP)
Quick Overview for PLK4 抗体 (HRP) (ABIN6987763)
抗原
See all PLK4 抗体适用
宿主
克隆类型
标记
应用范围
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交叉反应
- 人
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预测反应
- Mouse,Rat,Dog,Cow,Sheep,Rabbit
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic peptide derived from human PLK4/STK18
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亚型
- IgG
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anti-Polo-Like Kinase 4 (PLK4) (AA 1-110) antibody
PLK4 适用: 人 ELISA 宿主: 小鼠 Monoclonal 1C8 unconjugated
anti-Polo-Like Kinase 4 (PLK4) antibodyPLK4 适用: 人, 小鼠, 大鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Polo-Like Kinase 4 (PLK4) (AA 724-758) antibodyPLK4 适用: 人 WB 宿主: 兔 Polyclonal RB53118 unconjugated
anti-Polo-Like Kinase 4 (PLK4) (AA 1-970) antibodyPLK4 适用: 人 IP 宿主: 兔 Polyclonal unconjugated
anti-Polo-Like Kinase 4 (PLK4) (AA 1-970) antibodyPLK4 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Polo-Like Kinase 4 (PLK4) (AA 641-970) antibodyPLK4 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- IHC-P 1:200-400
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
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有效期
- 12 months
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- PLK4 (Polo-Like Kinase 4 (PLK4))
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别名
- PLK4/STK18
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物质类
- Phage Protein
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背景
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Synonyms: PLK 4, PLK-4, PLK4_HUMAN, Polo like Kinase 4, Polo-like kinase 4, Protein serine/threonine kinase, SAK, Serine/Threonine Kinase 18, Serine/threonine kinase, Serine/threonine protein kinase 18, Serine/threonine protein kinase PLK4, Serine/threonine protein kinase Sak, Serine/threonine-protein kinase 18, Serine/threonine-protein kinase PLK4, Serine/threonine-protein kinase SAK, Snk Akin Kinase, STK 18.
Background: Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CENPJ/CPAP, CP110, CEP135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Its central role in centriole replication suggests a posible role in tumorigenesis, centrosome aberrations being frequently observed in tumors. Also involved in trophoblast differentiation by phosphorylating HAND1, leading to disrupt the interaction between HAND1 and MDFIC and activate HAND1. Phosphorylates CDC25C and CHEK2/CHK2.
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基因ID
- 10733
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UniProt
- O00444
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途径
- M Phase
抗原
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