VRK2 抗体 (AA 151-250) (Cy5)
Quick Overview for VRK2 抗体 (AA 151-250) (Cy5) (ABIN6984136)
抗原
See all VRK2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 151-250
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交叉反应
- 小鼠
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预测反应
- Human,Rat,Chicken
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic peptide derived from human VRK2
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亚型
- IgG
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anti-Vaccinia Related Kinase 2 (VRK2) (AA 260-360) antibody
VRK2 适用: 人 WB, ELISA, IF, RNAi 宿主: 小鼠 Monoclonal 3B10 unconjugated
anti-Vaccinia Related Kinase 2 (VRK2) (AA 1-508) antibodyVRK2 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Vaccinia Related Kinase 2 (VRK2) (AA 317-472) antibodyVRK2 适用: 人 ELISA, IF, IHC 宿主: 兔 Polyclonal unconjugated
anti-Vaccinia Related Kinase 2 (VRK2) (AA 1-508) antibodyVRK2 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Vaccinia Related Kinase 2 (VRK2) (Internal Region) antibodyVRK2 适用: 人, 小鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Vaccinia Related Kinase 2 (VRK2) (AA 151-250) antibodyVRK2 适用: 小鼠 WB, ELISA, IF (cc), IF (p), ICC, IHC (fro), IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Vaccinia Related Kinase 2 (VRK2) (Internal Region) antibodyVerified VRK2 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
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应用备注
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
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有效期
- 12 months
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- VRK2 (Vaccinia Related Kinase 2 (VRK2))
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别名
- VRK2
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背景
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Synonyms: Serine/threonine-protein kinase VRK2, VRK2, Vaccinia-related kinase 2
Background: Serine/threonine kinase that regulates several signal transduction pathways. Isoform 1 modulates the stress response to hypoxia and cytokines, such as interleukin-1 beta (IL1B) and this is dependent on its interaction with MAPK8IP1, which assembles mitogen-activated protein kinase (MAPK) complexes. Inhibition of signal transmission mediated by the assembly of MAPK8IP1-MAPK complexes reduces JNK phosphorylation and JUN-dependent transcription. Phosphorylates 'Thr-18' of p53/TP53, histone H3, and may also phosphorylate MAPK8IP1. Phosphorylates BANF1 and disrupts its ability to bind DNA and reduces its binding to LEM domain-containing proteins. Downregulates the transactivation of transcription induced by ERBB2, HRAS, BRAF, and MEK1. Blocks the phosphorylation of ERK in response to ERBB2 and HRAS. Can also phosphorylate the following substrates that are commonly used to establish in vitro kinase activity: casein, MBP and histone H2B, but it is not sure that this is physiologically relevant. Isoform 2 phosphorylates 'Thr-18' of p53/TP53, as well as histone H3. Reduces p53/TP53 ubiquitination by MDM2, promotes p53/TP53 acetylation by EP300 and thereby increases p53/TP53 stability and activity.
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基因ID
- 7444
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UniProt
- Q86Y07
抗原
-
