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SMAD7 抗体 (AA 1-100) (Biotin)

This anti-SMAD7 antibody is a 兔 多克隆 antibody detecting SMAD7 in ELISA, IHC (p) 和 IHC (fro). Suitable for 人, 小鼠 和 大鼠.
产品编号 ABIN6982967
发货至: 中国

Quick Overview for SMAD7 抗体 (AA 1-100) (Biotin) (ABIN6982967)

抗原

See all SMAD7 抗体
SMAD7 (SMAD, Mothers Against DPP Homolog 7 (SMAD7))

适用

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人, 小鼠, 大鼠

宿主

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  • 9
  • 1

克隆类型

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  • 9
多克隆

标记

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This SMAD7 antibody is conjugated to Biotin

应用范围

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ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
  • 抗原表位

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    • 1
    AA 1-100

    交叉反应

    人, 小鼠, 大鼠

    纯化方法

    Purified by Protein A.

    免疫原

    KLH conjugated synthetic peptide derived from human MADH7

    亚型

    IgG
  • 应用备注

    IHC-P 1:200-400
    IHC-F 1:100-500

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    1 μg/μL

    缓冲液

    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

    储存液

    ProClin

    注意事项

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    Store at -20°C for 12 months.

    有效期

    12 months
  • 抗原

    SMAD7 (SMAD, Mothers Against DPP Homolog 7 (SMAD7))

    别名

    MADH7

    背景

    Synonyms: hSMAD 7, hSMAD7, MAD (mothers against decapentaplegic Drosophila) homolog 7, MAD, Mad homolog 7, MAD mothers against decapentaplegic homolog 7, MADH 7, MADH 8, MADH8, Mothers Against Decapentaplegic Drosophila Homolog of 7, Mothers against decapentaplegic homolog 7, Mothers against decapentaplegic homolog 8, Mothers against DPP homolog 7, Mothers against DPP homolog 8, SMA- AND MAD-RELATED PROTEIN 7, SMAD 7, SMAD, SMAD family member 7, SMAD, mothers against DPP homolog 7 (Drosophila), SMAD, mothers against DPP homolog 7, Smad7, SMAD7_HUMAN

    Background: The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]

    基因ID

    4092

    UniProt

    O15105

    途径

    Interferon-gamma Pathway, Cell-Cell Junction Organization
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