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Importin 5 抗体 (AA 501-600) (Biotin)

This anti-Importin 5 antibody is a 兔 多克隆 antibody detecting Importin 5 in ELISA, IHC (p) 和 IHC (fro). Suitable for 大鼠.
产品编号 ABIN6982634
发货至: 中国

Quick Overview for Importin 5 抗体 (AA 501-600) (Biotin) (ABIN6982634)

抗原

See all Importin 5 (IPO5) 抗体
Importin 5 (IPO5)

适用

  • 20
  • 18
  • 5
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
大鼠

宿主

  • 30
  • 4

克隆类型

  • 32
  • 2
多克隆

标记

  • 14
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
This Importin 5 antibody is conjugated to Biotin

应用范围

  • 13
  • 13
  • 12
  • 6
  • 5
  • 5
  • 3
  • 2
  • 2
  • 1
ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
  • 抗原表位

    • 14
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 501-600

    交叉反应

    大鼠

    预测反应

    Human,Mouse,Cow,Sheep,Pig,Horse

    纯化方法

    Purified by Protein A.

    免疫原

    KLH conjugated synthetic peptide derived from human Karyopherin beta 3

    亚型

    IgG
  • 应用备注

    IHC-P 1:200-400
    IHC-F 1:100-500

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    1 μg/μL

    缓冲液

    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

    储存液

    ProClin

    注意事项

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    Store at -20°C for 12 months.

    有效期

    12 months
  • 抗原

    Importin 5 (IPO5)

    别名

    Karyopherin beta 3

    背景

    Synonyms: DKFZp686O1576, FLJ43041, IMB3, Imp5, Importin 5, Importin beta 3 subunit, Importin subunit beta 3, Importin subunit beta-3, Importin-5, IPO 5, IPO5, IPO5_HUMAN, Karyopherin beta 3, Karyopherin beta-3, KPNB3, MGC2068, Pse1, Ran binding protein 5, Ran GTP binding protein 5, Ran-binding protein 5, RanBP 5, RanBP5.

    Background: Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev.

    基因ID

    3843

    UniProt

    O00410

    途径

    Protein targeting to Nucleus
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