TEAD1 抗体
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北京 101111
Quick Overview for TEAD1 抗体 (ABIN6972853)
抗原
See all TEAD1 抗体适用
宿主
克隆类型
标记
应用范围
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产品特性
- TEAD1 (TEA Domain Family Member 1 (SV40 Transcriptional Enhancer Factor)) is a transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and cooperatively to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription in vivo in a cell-specific manner. The activation function appears to be mediated by a limiting cell-specific transcriptional intermediary factor (TIF). Involved in cardiac development. Binds to the M-CAT motif. TEAD1 antibody (pAb) was raised in a Rabbit host. It has been validated for use in Western blot, it has been shown to react with Human samples.
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纯化方法
- Affinity Purified
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免疫原
- This antibody was raised against a recombinant protein fragment within human TEAD1.
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亚型
- IgG
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anti-TEA Domain Family Member 1 (SV40 Transcriptional Enhancer Factor) (TEAD1) (AA 135-215) antibody
TEAD1 适用: 人 WB, IF, IHC, ChIP 宿主: 兔 Polyclonal unconjugated
anti-TEA Domain Family Member 1 (SV40 Transcriptional Enhancer Factor) (TEAD1) (Internal Region) antibodyTEAD1 适用: 人, 小鼠, 大鼠 WB, IF, IHC, ELISA, ICC 宿主: 兔 Polyclonal unconjugated
anti-TEA Domain Family Member 1 (SV40 Transcriptional Enhancer Factor) (TEAD1) (C-Term) antibodyTEAD1 适用: 人, 小鼠, 大鼠, 犬, Cow, 斑马鱼, 兔, Pig, 豚鼠, 马, 小鸡, 猴, Bat, 非洲爪蟾 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-TEA Domain Family Member 1 (SV40 Transcriptional Enhancer Factor) (TEAD1) (C-Term) antibodyTEAD1 适用: 人, 小鼠, 大鼠, 犬, Cow, 斑马鱼, 兔, 豚鼠, 马 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-TEA Domain Family Member 1 (SV40 Transcriptional Enhancer Factor) (TEAD1) (AA 135-215) antibodyTEAD1 适用: 人 WB, IF, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-TEA Domain Family Member 1 (SV40 Transcriptional Enhancer Factor) (TEAD1) antibodyTEAD1 适用: 人 WB, IP, ChIP 宿主: 兔 Monoclonal unconjugated
anti-TEA Domain Family Member 1 (SV40 Transcriptional Enhancer Factor) (TEAD1) antibodyKD Validated TEAD1 适用: 人 WB, FACS 宿主: 兔 Monoclonal 23GB2800 unconjugated Recombinant Antibody
anti-TEA Domain Family Member 1 (SV40 Transcriptional Enhancer Factor) (TEAD1) antibodyTEAD1 适用: 人, 小鼠, 大鼠 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-TEA Domain Family Member 1 (SV40 Transcriptional Enhancer Factor) (TEAD1) antibodyKD Validated TEAD1 适用: 人 WB, FACS 宿主: 兔 Monoclonal 23GB2795 unconjugated Recombinant Antibody
anti-TEA Domain Family Member 1 (SV40 Transcriptional Enhancer Factor) (TEAD1) antibodyTEAD1 适用: 人 WB 宿主: 兔 Monoclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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缓冲液
- Purified IgG in PBS with 30 % glycerol and 0.035 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.
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- TEAD1 (TEA Domain Family Member 1 (SV40 Transcriptional Enhancer Factor) (TEAD1))
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别名
- TEAD1
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分子量
- 60 kDa
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NCBI登录号
- NP_068780
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途径
- Regulation of Lipid Metabolism by PPARalpha
抗原
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