SUPT16H 抗体
Quick Overview for SUPT16H 抗体 (ABIN6972824)
抗原
See all SUPT16H 抗体适用
宿主
克隆类型
标记
应用范围
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产品特性
- Supt16H / Supt16 (suppressor of Ty 16 homolog (S. cerevisiae)) is a component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II). Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene (By similarity). Supt16H / Spt16 antibody (pAb) was raised in a Rabbit host. It has been validated for use in Western blot, it has been shown to react with Human samples.
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纯化方法
- Affinity Purified
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免疫原
- This antibody was raised against a synthetic peptide containing human Supt16H / Spt16.
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亚型
- IgG
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anti-FACT complex subunit SPT16 (SUPT16H) antibody
SUPT16H 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-FACT complex subunit SPT16 (SUPT16H) (AA 608-715) antibodySUPT16H 适用: 人 ELISA, WB 宿主: 小鼠 Monoclonal 1D12 unconjugated
anti-FACT complex subunit SPT16 (SUPT16H) (AA 187-282) antibodySUPT16H 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-FACT complex subunit SPT16 (SUPT16H) (C-Term) antibodySUPT16H 适用: 人, 小鼠 ELISA, WB, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-FACT complex subunit SPT16 (SUPT16H) antibodySUPT16H 适用: 人 WB, IHC, IHC (p) 宿主: 小鼠 Monoclonal 8D2 unconjugated
anti-FACT complex subunit SPT16 (SUPT16H) (Internal Region) antibodyVerified SUPT16H 适用: 人 ELISA, WB 宿主: 山羊 Polyclonal unconjugated
anti-FACT complex subunit SPT16 (SUPT16H) (C-Term) antibodySUPT16H 适用: 人 ELISA, WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-FACT complex subunit SPT16 (SUPT16H) (AA 77-126) antibodySUPT16H 适用: 人, 犬, Pig, 马, 兔, 猴, Bat WB 宿主: 兔 Polyclonal unconjugated
anti-FACT complex subunit SPT16 (SUPT16H) (AA 608-715) antibodySUPT16H 适用: 人 ELISA 宿主: 小鼠 Monoclonal 1F1 unconjugated
anti-FACT complex subunit SPT16 (SUPT16H) (AA 971-1020) antibodySUPT16H 适用: 人, 小鼠, 大鼠, 犬, Pig, Cow, 马, 兔, 猴, Bat, 非洲爪蟾 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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缓冲液
- Purified IgG in PBS with 30 % glycerol and 0.035 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.
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- SUPT16H (FACT complex subunit SPT16 (SUPT16H))
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别名
- Supt16H / Spt16
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分子量
- 140 kDa
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NCBI登录号
- NP_009123
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途径
- Chromatin Binding
抗原
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