MAF 抗体 (C-Term)
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Quick Overview for MAF 抗体 (C-Term) (ABIN6972305)
抗原
See all MAF 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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产品特性
- MAF (V-Maf Avian Musculoaponeurotic Fibrosarcoma Oncogene Homolog) acts as a transcriptional activator or repressor. Involved in embryonic lens fiber cell development. Recruits the transcriptional coactivators CREBBP and/or EP300 to crystallin promoters leading to up-regulation of crystallin gene during lens fiber cell differentiation. Activates the expression of IL4 in T helper 2 (Th2) cells. Increases T-cell susceptibility to apoptosis by interacting with MYB and decreasing BCL2 expression. Together with PAX6, transactivates strongly the glucagon gene promoter through the G1 element. Activates transcription of the CD13 proximal promoter in endothelial cells. Represses transcription of the CD13 promoter in early stages of myelopoiesis by affecting the ETS1 and MYB cooperative interaction. Involved in the initial chondrocyte terminal differentiation and the disappearance of hypertrophic chondrocytes during endochondral bone development. Binds to the sequence 5'-[GT]G[GC]N[GT]NCTCAGNN-3' in the L7 promoter. Binds to the T-MARE (Maf response element) sites of lens-specific alpha- and beta-crystallin gene promoters. Binds element G1 on the glucagon promoter. Binds an AT-rich region adjacent to the TGC motif (atypical Maf response element) in the CD13 proximal promoter in endothelial cells (By similarity). When overexpressed, represses anti-oxidant response element (ARE)-mediated transcription. Involved either as an oncogene or as a tumor suppressor, depending on the cell context. Binds to the ARE sites of detoxifying enzyme gene promoters. MAF antibody (pAb) was raised in a Rabbit host. It has been validated for use in Western blot, it has been shown to react with Human samples.
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纯化方法
- Affinity Purified
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免疫原
- This antibody was raised against a peptide within the C-terminal region of human MAF.
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亚型
- IgG
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anti-V-Maf Musculoaponeurotic Fibrosarcoma Oncogene Homolog (Avian) (MAF) (C-Term) antibody
MAF 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-V-Maf Musculoaponeurotic Fibrosarcoma Oncogene Homolog (Avian) (MAF) (N-Term) antibodyMAF 适用: 人, 小鼠, 大鼠, Cow, 犬, 小鸡, 豚鼠, 猴, 非洲爪蟾 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-V-Maf Musculoaponeurotic Fibrosarcoma Oncogene Homolog (Avian) (MAF) (AA 304-403) antibodyMAF 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 6B8 unconjugated
anti-V-Maf Musculoaponeurotic Fibrosarcoma Oncogene Homolog (Avian) (MAF) (AA 304-403) antibodyMAF 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 6B6 unconjugated
anti-V-Maf Musculoaponeurotic Fibrosarcoma Oncogene Homolog (Avian) (MAF) (N-Term) antibodyMAF 适用: 人, 小鼠, 大鼠, Cow, 斑马鱼, 犬, 小鸡 WB 宿主: 兔 Polyclonal unconjugated
anti-V-Maf Musculoaponeurotic Fibrosarcoma Oncogene Homolog (Avian) (MAF) (AA 341-403) antibodyMAF 适用: 人, 小鼠 ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-V-Maf Musculoaponeurotic Fibrosarcoma Oncogene Homolog (Avian) (MAF) (C-Term) antibodyMAF 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-V-Maf Musculoaponeurotic Fibrosarcoma Oncogene Homolog (Avian) (MAF) antibodyMAF 适用: 人 WB, IP 宿主: 兔 Monoclonal unconjugated
anti-V-Maf Musculoaponeurotic Fibrosarcoma Oncogene Homolog (Avian) (MAF) antibodyMAF 适用: 人 WB, FACS 宿主: 兔 Monoclonal 24GB650 unconjugated Recombinant Antibody
anti-V-Maf Musculoaponeurotic Fibrosarcoma Oncogene Homolog (Avian) (MAF) antibodyMAF 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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缓冲液
- Purified IgG in PBS with 30 % glycerol and 0.035 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.
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- MAF (V-Maf Musculoaponeurotic Fibrosarcoma Oncogene Homolog (Avian) (MAF))
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别名
- MAF
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分子量
- 50 kDa
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NCBI登录号
- NP_005351
抗原
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