KLF4 抗体
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北京 101111
Quick Overview for KLF4 抗体 (ABIN6972260)
抗原
See all KLF4 抗体适用
宿主
克隆类型
标记
应用范围
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产品特性
- KLF4 (Kruppel-like factor 4) is a transcription factor that binds GC-rich DNA sequences having a consensus core DNA binding sequence of CACCC. It is a member of the Kruppel-like factor (KLF) family, highly expressed in the gastrointestinal tract, skin and other epithelial tissues. Krüppel-like factors are a family of zinc-finger transcription factors that play important roles in many fundamental biologic processes including development, proliferation, differentiation, and apoptosis. KLF4 can function both as an activator and repressor of transcription, depending on the gene targeted. Generally, KLF4 serves as a cell cycle regulator, and it may be a tumor suppressor. KLF4 also appears to function as an oncogene in some situations. Additionally, overexpression of KLF4 (along with Oct3/4, Sox2 and c-Myc) can transform mouse fibroblasts into a state resembling embryonic stem cells (ES cells), referred to as Induced Pluripotency. KLF4 antibody (pAb) was raised in a Rabbit host. It has been validated for use in Western blot, it has been shown to react with Human samples, but it is predicted that it will react with a wide range of sample types.
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纯化方法
- Affinity Purified
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免疫原
- This KLF4 antibody was raised against recombinant full-length human KLF4.
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亚型
- IgG
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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缓冲液
- Purified IgG in PBS with 30 % glycerol and 0.035 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.
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- KLF4 (Kruppel-Like Factor 4 (Gut) (KLF4))
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别名
- KLF4
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分子量
- 55 kDa
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NCBI登录号
- NP_004226
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途径
- Peptide Hormone Metabolism, Stem Cell Maintenance
抗原
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