HIRA 抗体 (AA 421-729)
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Quick Overview for HIRA 抗体 (AA 421-729) (ABIN6971735)
抗原
See all HIRA 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 421-729
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产品特性
- HIRA (DGCR1, TUP1) is a histone chaperone that preferentially places the variant Histone H3.3 in nucleosomes, replacing canonical Histone H3 during the cell cycle. HIRA is required for the periodic repression of histone gene transcription during the cell cycle and when complexed with ASF1a is involved in the formation of the senescence-associated heterochromatin foci. HIRA antibody (mAb) (Clone WC15) was raised in a Mouse host. It has been validated for use in Immunoprecipitation and Western blot, it has been shown to react with Human and Mouse samples.
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纯化方法
- Protein G Chromatography
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免疫原
- This HIRA antibody was raised against a GST-fusion protein containing residues 421-729 of human HIRA.
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亚型
- IgG
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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缓冲液
- Purified IgG in 70 mM Tris ( pH 8), 105 mM NaCl, 31 mM glycine, 0.07 mM EDTA, 30 % glycerol and 0.035 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.
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- HIRA (HIR Histone Cell Cycle Regulation Defective Homolog A (HIRA))
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别名
- HIRA
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分子量
- 120 kDa
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NCBI登录号
- NP_003316
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途径
- Chromatin Binding
抗原
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