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APOB 抗体 (Biotin)

Cited in 5+ publications. This Biotin-conjugated 小鼠 单克隆 anti-APOB antibody (Clone LDL 11) specifically detects APOB in WB 和 ELISA. The antibody is reactive with 人 和 Non-Human Primate samples.
产品编号 ABIN6963945
发货至: 中国
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Tel +86 (0512) 65829739 传真 +86 (010) 6788 5057

Quick Overview for APOB 抗体 (Biotin) (ABIN6963945)

抗原

See all APOB 抗体
APOB (Apolipoprotein B (APOB))

适用

  • 115
  • 27
  • 26
  • 6
  • 1
人, Non-Human Primate

宿主

  • 80
  • 46
  • 14
  • 2
  • 2
小鼠

克隆类型

  • 84
  • 59
单克隆

标记

  • 62
  • 23
  • 15
  • 7
  • 6
  • 5
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
This APOB antibody is conjugated to Biotin

应用范围

  • 85
  • 46
  • 41
  • 31
  • 30
  • 19
  • 17
  • 9
  • 7
  • 6
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Western Blotting (WB), ELISA

克隆位点

LDL 11
  • 特异性

    Native apoB in the form of LDL.

    交叉反应 (详细)

    The monoclonal antibody cross-reacts with apoB from non-human primates.

    纯化方法

    Purified from in vitro cultures by protein G affinity chromatography.

    免疫原

    Human LDL

    亚型

    IgG1
  • 应用备注

    For quantification of apoB in serum/plasma samples and cell culture supernatants using ELISA. LDL 11 is recommended as detection mAb in combination with coating mAb LDL 20/17 . The antibody is also suitable for immunoprecipitation and Western blot.

    说明

    Biotinylated through reaction with a N-hydroxysuccinimide ester of biotin.

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    1 mg/mL

    缓冲液

    supplied at 1 mg/mL in PBS with 0.02 % sodium azide

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    储存方法

    Store product at 4-8°C or frozen at -20°C or below. Avoid repeated freezing/ thawing.

    有效期

    18 months
  • Yu, Rimbert, Palmer, Toyohara, Xia, Xia, Ferreira, Chen, Chen, Loaiza, Horwitz, Kacergis, Zhao, Soukas, Kuivenhoven, Kathiresan, Cowan: "GPR146 Deficiency Protects against Hypercholesterolemia and Atherosclerosis." in: Cell, Vol. 179, Issue 6, pp. 1276-1288.e14, (2020) (PubMed).

    Cayo, Mallanna, Di Furio, Jing, Tolliver, Bures, Urick, Noto, Pashos, Greseth, Czarnecki, Traktman, Yang, Morrisey, Grompe, Rader, Duncan: "A Drug Screen using Human iPSC-Derived Hepatocyte-like Cells Reveals Cardiac Glycosides as a Potential Treatment for Hypercholesterolemia." in: Cell stem cell, Vol. 20, Issue 4, pp. 478-489.e5, (2017) (PubMed).

    Vu, Bemis, Benson, Bista, Carney, Fahrner, Lee, Liu, Lonkar, Milne, Nichols, Picarella, Shoelson, Smith, Ting, Wensley, Yeager, Zimmer, Jirousek: "Synthesis and Characterization of Fatty Acid Conjugates of Niacin and Salicylic Acid." in: Journal of medicinal chemistry, Vol. 59, Issue 3, pp. 1217-31, (2016) (PubMed).

    Bissig-Choisat, Wang, Legras, Saha, Chen, Bell, Pankowicz, Hill, Barzi, Leyton, Leung, Kruse, Himes, Goss, Wilson, Chan, Lagor, Bissig: "Development and rescue of human familial hypercholesterolaemia in a xenograft mouse model." in: Nature communications, Vol. 6, pp. 7339, (2015) (PubMed).

    Derwall, Malhotra, Lai, Beppu, Aikawa, Seehra, Zapol, Bloch, Yu: "Inhibition of bone morphogenetic protein signaling reduces vascular calcification and atherosclerosis." in: Arteriosclerosis, thrombosis, and vascular biology, Vol. 32, Issue 3, pp. 613-22, (2012) (PubMed).

  • 抗原

    APOB (Apolipoprotein B (APOB))

    别名

    apoB

    基因ID

    338

    途径

    Lipid Metabolism
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