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IL-4 抗体

This anti-IL-4 antibody is a 大鼠 单克隆 antibody detecting IL-4 in ELISA, FACS, IF 和 IHC (fro). Suitable for 小鼠.
产品编号 ABIN6961773
发货至: 中国

Quick Overview for IL-4 抗体 (ABIN6961773)

抗原

See all IL-4 (IL4) 抗体
IL-4 (IL4) (Interleukin 4 (IL4))

适用

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小鼠

宿主

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大鼠

克隆类型

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单克隆

标记

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This IL-4 antibody is un-conjugated

应用范围

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ELISA, Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Frozen Sections) (IHC (fro))

克隆位点

11B11
  • 纯化方法

    This monoclonal antibody preparation was purified from tissue culture supernatant via affinity chromatography. For In Vivo Ready™ (IVR) products, each preparation is also evaluated for endotoxin levels using the LAL assay. It is recommended to store the product undiluted at 4°C. Do not freeze.

    亚型

    IgG1 kappa
  • 应用备注

    This purified format is guaranteed to be >90 % pure as determined by SDS-PAGE analysis.

    说明

    0.5 mg/mL

    限制

    仅限研究用
  • 缓冲液

    10 mM NaH2PO4, 150 mM NaCl, 0.09 % Sodium azide, pH 7.2

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C

    储存方法

    2-8°C

    有效期

    12 months
  • 抗原

    IL-4 (IL4) (Interleukin 4 (IL4))

    别名

    IL-4

    背景

    The 11B11 antibody binds to mouse Interleukin-4 (IL-4), a 14 kDa cytokine that is largely secreted by activated T cells of the Th2 subset, and to some degree by NKT and mast cells. This cytokine acts as a stimulatory factor for B cells, inducing their proliferation and differ- entiation, as well as playing a role in immunoglobulin class-switching. IL-4 may also provide autocrine stimulation for T cells, and affect the function of antigen presenting cells such as macrophages and dendritic cells. IL-4 can bind and signal via three cell surface receptor types: CD124 by itself, CD124 in combination with the common gamma chain (type I complex), or CD124 combined with CD213a1 (type II complex).The 11B11 antibody is widely used for detection of intracellular levels of IL-4 protein by flow cytometry, as well as for analysis of soluble cytokine as measured by ELISA, and in functional assays to neutralization cytokine-receptor interactions.

    基因ID

    16189

    UniProt

    P07750

    途径

    JAK/STAT Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Proton Transport, Activated T Cell Proliferation
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