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IL-2 抗体 (APC)

This anti-IL-2 antibody is a 大鼠 单克隆 antibody detecting IL-2 in FACS. Suitable for 小鼠.
产品编号 ABIN7278034
发货至: 中国

Quick Overview for IL-2 抗体 (APC) (ABIN7278034)

抗原

See all IL-2 (IL2) 抗体
IL-2 (IL2) (Interleukin 2 (IL2))

适用

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小鼠

宿主

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大鼠

克隆类型

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单克隆

标记

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This IL-2 antibody is conjugated to APC

应用范围

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Flow Cytometry (FACS)

克隆位点

JES6-5H4
  • 纯化方法

    This monoclonal antibody was purified from tissue culture supernatant via affinity chromatography. The purified antibody was conjugated under optimal conditions, with unreacted dye removed from the preparation. It is recommended to store the product undiluted at 4°C, and protected from prolonged exposure to light. Do not freeze.

    亚型

    IgG2b kappa
  • 应用备注

    This antibody preparation has been quality-tested for flow cytometry using mouse spleen cells, or an appropriate cell type (where indi- cated). The amount of antibody required for optimal staining of a cell sample should be determined empirically in your system.

    说明

    0.2 mg/mL

    限制

    仅限研究用
  • 缓冲液

    10 mM NaH2PO4, 150 mM NaCl, 0.09 % Sodium azide, 0.1 % gelatin, pH 7.2

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C

    储存方法

    2-8°C protected from light

    有效期

    12 months
  • 抗原

    IL-2 (IL2) (Interleukin 2 (IL2))

    别名

    IL-2

    背景

    The JES6-5H4 antibody binds to mouse Interleukin-2 (IL-2), a 17 kDa cytokine that is secreted by activated T cells. This cytokine acts as an autocrine stimulatory factor for T cell proliferation, differentiation and survival, as well as being an effective activator of B cells and inducer of NK cell cytotoxic functions. IL-2 plays a key modulatory role in the differentiation of T cells toward either Th17 or T regulatory (Treg) cell types and is important for Treg cell function. The IL-2 receptor (IL-2R) is a complex consisting of an IL-2R alpha chain (CD25), along with the IL-2R beta chain (CD122) and the common gamma chain (CD132). IL-2 may also bind with low affinity to the T cell surface protein CD25 alone, although this interaction does not induce cell signaling.The JES6-5H4 antibody is extensively used for intracellular detection of IL-2 by flow cytometry, for detection of soluble cytokine in ELISA, and as a neutralizing reagent in vitro and in vivo.

    基因ID

    16183

    UniProt

    P04351

    途径

    JAK/STAT Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Activated T Cell Proliferation
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