Catalase 抗体 (AA 23-226)
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Quick Overview for Catalase 抗体 (AA 23-226) (ABIN6961050)
抗原
See all Catalase (CAT) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 23-226
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纯化方法
- Purified from cell culture supernatant by affinity chromatography
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免疫原
- Recombinant human CS1 (Ser23-Met226) (ABIN6961075) produced by using human HEK293 cells
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亚型
- IgG
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应用备注
- Flow Cyt 1/100
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 50 % Glycerol, PBS, pH 7.4, 0.1 % BSA, 0.1 % Procline 300
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
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有效期
- 12 months
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- Catalase (CAT)
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别名
- CS1
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背景
- Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Isoform 1 mediates NK cell activation through a SH2D1A-independent extracellular signal-regulated ERK-mediated pathway (PubMed:11698418). Positively regulates NK cell functions by a mechanism dependent on phosphorylated SH2D1B. Downstream signaling implicates PLCG1, PLCG2 and PI3K (PubMed:16339536). In addition to heterotypic NK cells-target cells interactions also homotypic interactions between NK cells may contribute to activation. However, in the absence of SH2D1B, inhibits NK cell function. Acts also inhibitory in T-cells (By similarity). May play a role in lymphocyte adhesion (PubMed:11802771). In LPS-activated monocytes negatively regulates production of proinflammatory cytokines (PubMed:23695528).
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分子量
- 37 kDa
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基因ID
- 57823
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UniProt
- Q9NQ25
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途径
- Cellular Glucan Metabolic Process, Cell RedoxHomeostasis, Photoperiodism
抗原
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