Recombinant SARS-CoV-2 Spike 抗体 (AA 16-685)
Quick Overview for Recombinant SARS-CoV-2 Spike 抗体 (AA 16-685) (ABIN6953151)
抗原
See all SARS-CoV-2 Spike 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 16-685
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原理
- S Recombinant Monoclonal Antibody
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产品特性
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Recombinant anti-SARS-CoV-2 spike is expressed from 293 cells (HEK293) ,It is a chimeric monoclonal antibody combining the mouse variable regions with the constant domains of human IgG1.
Monoclonal mouse (varialbe region) / human (kappa / IgG1 constant)chimeric antibody.
AA 16-685 -
纯化方法
- Affinity-chromatography
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免疫原
- Recombinant Human Novel Coronavirus Spike glycoprotein (S) (16-685aa) (CSB-MP3324GMY)
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亚型
- Ig kappa, IgG1
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anti-SARS-CoV-2 Spike (C-Term) antibody
适用: SARS Coronavirus-2 (SARS-CoV-2), SARS Coronavirus (SARS-CoV) ELISA, WB, IF, IHC 宿主: 兔 Polyclonal unconjugated
anti-SARS-CoV-2 Spike antibody适用: SARS Coronavirus-2 (SARS-CoV-2), SARS CoV-2 Beta, SARS CoV-2 Gamma, SARS CoV-2 Alpha ELISA, WB 宿主: 兔 Polyclonal unconjugated
anti-SARS-CoV-2 Spike (AA 319-541) antibodyAnimal-Free 适用: SARS Coronavirus-2 (SARS-CoV-2) ELISA, WB, FACS, IF 宿主: 小鼠 Monoclonal AB68-A09 unconjugated Recombinant Antibody
anti-SARS-CoV-2 Spike (AA 319-541), (Receptor Binding Domain) antibody (Fc Tag)适用: SARS Coronavirus-2 (SARS-CoV-2) ELISA, Neut, GICA 宿主: Human Monoclonal A1 Fc Tag single-domain Antibody (sdAb) Recombinant Antibody
anti-SARS-CoV-2 Spike antibody适用: SARS Coronavirus-2 (SARS-CoV-2) ELISA, WB 宿主: Human Monoclonal AM004414 (414-4) unconjugated Recombinant Antibody
anti-SARS-CoV-2 Spike antibody适用: SARS Coronavirus-2 (SARS-CoV-2) ELISA 宿主: Human Monoclonal AM015553 (553-15) unconjugated Recombinant Antibody
anti-SARS-CoV-2 Spike (AA 319-541) antibody适用: SARS Coronavirus-2 (SARS-CoV-2) ELISA, FACS 宿主: 兔 Monoclonal DM54 unconjugated Recombinant Antibody
anti-SARS-CoV-2 Spike (AA 16-685) antibody (Fc Tag,Biotin)适用: SARS Coronavirus-2 (SARS-CoV-2) ELISA 宿主: 小鼠 Monoclonal H6 Fc Tag,Biotin scFv fragment Recombinant Antibody
anti-SARS-CoV-2 Spike (AA 16-685) antibody (Fc Tag,HRP)适用: SARS Coronavirus-2 (SARS-CoV-2) ELISA 宿主: 小鼠 Monoclonal H6 Fc Tag,HRP scFv fragment Recombinant Antibody
anti-SARS-CoV-2 Spike (RBD) antibody适用: SARS Coronavirus-2 (SARS-CoV-2) WB 宿主: 山羊 Polyclonal unconjugated
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应用备注
- ELISA:1:10000-1:50000, GICA:1:500-1:25000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 -
储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze
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- SARS-CoV-2 Spike
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别名
- SARS-CoV-2 (SARS-CoV-2/ 2019-nCoV) S
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背景
- Spike glycoprotein comprises two functional subunits responsible for binding to the host cell receptor (S1 subunit) and fusion of the viral and cellular membranes (S2 subunit). For many coronavirus (CoVs), S is cleaved at the boundary between the S1 and S2 subunits, which remain non-covalently bound in the prefusion conformation. The distal S1 subunit comprises the receptor-binding domain(s) and contributes to stabilization of the prefusion state of the membrane-anchored S2 subunit that contains the fusion machinery. S is further cleaved by host proteases at the so-called S2' site located immediately upstream of the fusion peptide in all CoVs. This cleavage has been proposed to activate the protein for membrane fusion via extensive irreversible conformational changes. However, different CoVs use distinct domains within the S1 subunit to recognize a variety of attachment and entry receptors, depending on the viral species. Endemic human coronaviruses OC43 and HKU1 attach via their S domain A to 5-N-acetyl-9-O-acetyl-sialosides found on glycoproteins and glycolipids at the host cell surface to enable entry into susceptible cells. MERS-CoV S uses domain A to recognize non-acetylated sialoside attachment receptors, which likely promote subsequent binding of domain B to the entry receptor, dipeptidyl-peptidase 4. SARS-CoV and several SARS-related coronaviruses (SARSr-CoV) interact directly with angiotensin-converting enzyme 2 (ACE2) via SB to enter target cells.
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基因ID
- 43740568
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UniProt
- P0DTC2
抗原
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