Polyclonal antibody raised in rabbit against human HDAC3 (Histone deacetylase 3), using two KLH-conjugated synthetic peptides from the central and the C-terminal part of the protein, respectively.
ChIP/ChIP-seq 2 μg:ChIP ELISA 1:10,000 WB not recommended
限制
仅限研究用
状态
Liquid
浓度
1.7 μg/μL
缓冲液
PBS, 0.05 % azide
储存液
Sodium azide
注意事项
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
储存条件
-20 °C
抗原
HDAC3
(Histone Deacetylase 3 (HDAC3))
别名
HDAC3
背景
HDAC3 (UniProt/Swiss-Prot entry O15379) catalyses the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) and on some other non-histone substrates. Acetylation and deacetylation of these highly conserved lysine residues is important for the control of gene expression. When tethered to a promoter, HDAC3 represses transcription and therefore plays an important role in transcriptional regulation, cell cycle progression and developmental events. HDAC3 probably participates in the regulation of transcription through its binding to the YY1 transcription factor, increasing YY1 repression. HDAC3 also downregulates p53 and is considered a potential tumor suppressor gene.