HDAC3 抗体 (C-Term)
Our Local Distributor
北京 101111
Quick Overview for HDAC3 抗体 (C-Term) (ABIN6952382)
抗原
See all HDAC3 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- C-Term
-
特异性
- Polyclonal antibody raised in rabbit against human HDAC3 (Histone deacetylase 3), using two KLH-conjugated synthetic peptides from the central and the C-terminal part of the protein, respectively.
-
纯化方法
- Peptide affinity purified
-
免疫原
- synthetic peptide
-
-
-
-
应用备注
-
ChIP/ChIP-seq 2 μg:ChIP
ELISA 1:10,000
WB not recommended -
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
浓度
- 1.7 μg/μL
-
缓冲液
- PBS, 0.05 % azide
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C
-
-
- HDAC3 (Histone Deacetylase 3 (HDAC3))
-
别名
- HDAC3
-
背景
- HDAC3 (UniProt/Swiss-Prot entry O15379) catalyses the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) and on some other non-histone substrates. Acetylation and deacetylation of these highly conserved lysine residues is important for the control of gene expression. When tethered to a promoter, HDAC3 represses transcription and therefore plays an important role in transcriptional regulation, cell cycle progression and developmental events. HDAC3 probably participates in the regulation of transcription through its binding to the YY1 transcription factor, increasing YY1 repression. HDAC3 also downregulates p53 and is considered a potential tumor suppressor gene.
-
UniProt
- O15379
-
途径
- Neurotrophin Signaling Pathway, Regulation of Lipid Metabolism by PPARalpha, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development
抗原
-