BRD4 抗体 (N-Term)
Our Local Distributor
北京 101111
Quick Overview for BRD4 抗体 (N-Term) (ABIN6952374)
抗原
See all BRD4 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- N-Term
-
特异性
- Polyclonal antibody raised in rabbit against human BRD4 (Bromodomain Containing 4), using two KLH-conjugated synthetic peptides from the N-terminal and central part of the protein, respectively.
-
纯化方法
- Peptide affinity purified
-
免疫原
- synthetic peptide
-
-
-
-
应用备注
-
ChIP 2 μg:ChIP
ELISA 1:10,000
WB 1:1,000 -
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
浓度
- 2.6 μg/μL
-
缓冲液
- PBS, 0.05 % azide, 0.05 % ProClin300
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C
-
-
- BRD4 (Bromodomain Containing 4 (BRD4))
-
别名
- BRD4
-
背景
- BRD4 (UniProt/Swiss-Prot entry O60885) is a chromatin reader protein that binds acetylated histones. It remains associated with acetylated chromatin throughout the entire cell cycle and provides epigenetic memory for gene transcription by preserving an acetylated chromatin status. As such, it plays a key role in the transmission of epigenetic memory across cell divisions. BRD4 promotes phosphorylation of Ser-2 of the C-terminal domain (CTD) of RNA polymerase II and plays a key role in regulating the transcription of signal-inducible genes. It has been implicated in a translocation of chromosome 19 which causes an upper respiratory tract carcinoma.
-
UniProt
- O60885
-
途径
- Chromatin Binding, SARS-CoV-2 Protein Interactome
抗原
-