XPO5 抗体
Quick Overview for XPO5 抗体 (ABIN6945398)
抗原
See all XPO5 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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交叉反应
- 人, 小鼠, 大鼠
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纯化方法
- Purified by Protein A.
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免疫原
- Recombinant protein within human Exportin-5 aa 1-200.
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亚型
- IgG
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anti-Exportin 5 (XPO5) (AA 1-280) antibody
XPO5 适用: 人 WB, IF, IP, ELISA 宿主: 小鼠 Monoclonal 2C5-1B3 unconjugated
anti-Exportin 5 (XPO5) (AA 925-1204) antibodyXPO5 适用: 人 WB, IF, IP 宿主: 兔 Polyclonal unconjugated
anti-Exportin 5 (XPO5) (AA 1-1204) antibodyXPO5 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Exportin 5 (XPO5) (AA 1-1204) antibodyXPO5 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Exportin 5 (XPO5) antibodyXPO5 适用: 人, 小鼠, 大鼠 WB, IHC, IF, IC 宿主: 兔 Polyclonal unconjugated
anti-Exportin 5 (XPO5) (AA 190-239) antibodyXPO5 适用: 人, 小鼠, 大鼠, Cow WB 宿主: 兔 Polyclonal unconjugated
anti-Exportin 5 (XPO5) (AA 182-231) antibodyXPO5 适用: 人, 小鼠, 大鼠, 豚鼠, 马 WB 宿主: 兔 Polyclonal unconjugated
anti-Exportin 5 (XPO5) (AA 1115-1164) antibodyXPO5 适用: 人, 小鼠, 大鼠, 豚鼠, 马, 兔, Bat, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Exportin 5 (XPO5) (N-Term) antibodyXPO5 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Exportin 5 (XPO5) (AA 2-180) antibodyXPO5 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB 1:300-5000
FCM 1:20-100
IHC-P 1:200-400 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C for 12 months.
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有效期
- 12 months
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- XPO5 (Exportin 5 (XPO5))
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别名
- XPO5
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背景
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Synonyms: Exportin-5, Ran-binding protein 21, Exp5, XPO5, KIAA1291, RANBP21
Background: Mediates the nuclear export of proteins bearing a double-stranded RNA binding domain (dsRBD) and double-stranded RNAs (cargos). XPO5 in the nucleus binds cooperatively to the RNA and to the GTPase Ran in its active GTP-bound form. Proteins containing dsRBDs can associate with this trimeric complex through the RNA. Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause disassembly of the complex and release of the cargo from the export receptor. XPO5 then returns to the nuclear compartment by diffusion through the nuclear pore complex, to mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Overexpression may in some circumstances enhance RNA-mediated gene silencing (RNAi). Mediates nuclear export of isoform 5 of ADAR/ADAR1 in a RanGTP-dependent manner. Mediates the nuclear export of micro-RNA precursors, which form short hairpins. Also mediates the nuclear export of synthetic short hairpin RNAs used for RNA interference. In some circumstances can also mediate the nuclear export of deacylated and aminoacylated tRNAs. Specifically recognizes dsRNAs that lack a 5'-overhang in a sequence-independent manner, have only a short 3'-overhang, and that have a double-stranded length of at least 15 base-pairs. Binding is dependent on Ran-GTP.
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基因ID
- 57510
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UniProt
- Q9HAV4
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途径
- Regulatory RNA Pathways, Protein targeting to Nucleus
抗原
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