XDH 抗体
Quick Overview for XDH 抗体 (ABIN6945395)
抗原
See all XDH 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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    - 
                                            交叉反应
- 人, 小鼠, 大鼠
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                                            纯化方法
- Purified by Protein A.
- 
                                            免疫原
- Recombinant protein within human Xanthine Oxidase aa 100-300.
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                                            亚型
- IgG
 
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                                            应用备注
- 
                        WB 1:300-5000
 IHC-P 1:200-400
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                                            限制
- 仅限研究用
 
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                                            状态
- Liquid
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                                            浓度
- 1 μg/μL
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                                            缓冲液
- Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.
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                                            储存液
- ProClin
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                                            注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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                                            储存条件
- -20 °C
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                                            储存方法
- Store at -20°C for 12 months.
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                                            有效期
- 12 months
 
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    - XDH (Xanthine Dehydrogenase (XDH))
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                                            别名
- Xanthine Oxidase
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                                            背景
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                        Synonyms: Xanthine dehydrogenase/oxidase, Xanthine dehydrogenase, Xanthine oxidase, Xanthine oxidoreductase, XD, XO, XOR, XDH, XDHA Background: The process of metabolizing purines to a common molecule known as xanthine is an essential process for the proper shuttling of uric acid. Xanthine oxidase is a flavoprotein enzyme that coordinates molybdenum and utilizes NAD+ as an electron acceptor to catalyze the oxidation of hypoxanthine to xanthine and then to uric acid. The predominant form of this enzyme is xanthine dehydrogenase, which is a homodimer that can be converted to xanthine oxidase by sulfhydryl oxidation or proteolytic modification. Xanthine oxidase is present in species ranging from bacteria to human and is ubiquitously expressed in mammalian tissues. In the oxidase form, this enzyme is coupled to the generation of free radicals. Individuals showing marked elevation of serum xanthine oxidase is suggestive of chronic liver disease and cholestasis, which is a condition defined by hepatic obstruction. Hepatic obstruction causes bile salts, the bile pigment bilirubin, and fats to accumulate in the blood stream instead of being eliminated normally. The clinical consequences of defects in xanthine oxidase range from mild to severe and even contribute to fatal disorders. 
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                                            基因ID
- 7498
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                                            UniProt
- P47989
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                                            途径
- Positive Regulation of Endopeptidase Activity
 抗原
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