TP53INP1 抗体
Our Local Distributor
北京 101111
Quick Overview for TP53INP1 抗体 (ABIN6945196)
抗原
See all TP53INP1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
-
-
交叉反应
- 人, 小鼠, 大鼠
-
纯化方法
- Purified by Protein A.
-
免疫原
- Full length recombinant protein of human TP53INP1
-
亚型
- IgG
-
-
anti-Tumor Protein P53 Inducible Nuclear Protein 1 (TP53INP1) (AA 138-205) antibody
TP53INP1 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Tumor Protein P53 Inducible Nuclear Protein 1 (TP53INP1) (Internal Region) antibodyTP53INP1 适用: 人, 小鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Tumor Protein P53 Inducible Nuclear Protein 1 (TP53INP1) antibodyKO Validated TP53INP1 适用: 人 WB, FACS 宿主: 兔 Monoclonal 25GB2710 unconjugated Recombinant Antibody
anti-Tumor Protein P53 Inducible Nuclear Protein 1 (TP53INP1) (AA 181-210), (C-Term) antibodyTP53INP1 适用: 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB29563 unconjugated
anti-Tumor Protein P53 Inducible Nuclear Protein 1 (TP53INP1) (AA 36-64), (N-Term) antibodyTP53INP1 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB29674 unconjugated
anti-Tumor Protein P53 Inducible Nuclear Protein 1 (TP53INP1) (N-Term) antibodyTP53INP1 适用: 人, 小鼠, 大鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
anti-Tumor Protein P53 Inducible Nuclear Protein 1 (TP53INP1) (C-Term) antibodyTP53INP1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Tumor Protein P53 Inducible Nuclear Protein 1 (TP53INP1) (C-Term) antibodyTP53INP1 适用: 人, 猴 WB, IHC, IP 宿主: 兔 Polyclonal unconjugated
anti-Tumor Protein P53 Inducible Nuclear Protein 1 (TP53INP1) (AA 188-218), (C-Term) antibodyTP53INP1 适用: 人, 小鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
anti-Tumor Protein P53 Inducible Nuclear Protein 1 (TP53INP1) (AA 43-72), (N-Term) antibodyTP53INP1 适用: 人 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
-
WB 1:300-5000
IHC-P 1:200-400
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 -
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
浓度
- 1 μg/μL
-
缓冲液
- Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.
-
储存液
- ProClin
-
注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
-
储存条件
- 4 °C,-20 °C
-
储存方法
- Store at 4°C for up to 2 weeks. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
-
有效期
- 12 months
-
-
- TP53INP1 (Tumor Protein P53 Inducible Nuclear Protein 1 (TP53INP1))
-
别名
- TP53INP1
-
背景
-
Synonyms: Tumor protein p53-inducible nuclear protein 1, Stress-induced protein, p53-dependent damage-inducible nuclear protein 1, p53DINP1, TP53INP1, P53 DINP1, SIP
Background: Antiproliferative and proapoptotic protein involved in cell stress response which acts as a dual regulator of transcription and autophagy. Acts as a positive regulator of autophagy. In response to cellular stress or activation of autophagy, relocates to autophagosomes where it interacts with autophagosome-associated proteins GABARAP, GABARAPL1/L2, MAP1LC3A/B/C and regulates autophagy. Acts as an antioxidant and plays a major role in p53/TP53-driven oxidative stress response. Possesses both a p53/TP53-independent intracellular reactive oxygen species (ROS) regulatory function and a p53/TP53-dependent transcription regulatory function. Positively regulates p53/TP53 and p73/TP73 and stimulates their capacity to induce apoptosis and regulate cell cycle. In response to double-strand DNA breaks, promotes p53/TP53 phosphorylation on 'Ser-46' and subsequent apoptosis. Acts as a tumor suppressor by inducing cell death by an autophagy and caspase-dependent mechanism. Can reduce cell migration by regulating the expression of SPARC.
-
基因ID
- 94241
-
UniProt
- Q96A56
抗原
-
