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SUN1 抗体

The 兔 单克隆 anti-SUN1 antibody (Clone 2C4) (ABIN6945098) specifically detects SUN1 in WB, FACS, IHC (p), IF (cc) 和 IF (p). The antibody is reactive with 人 和 大鼠 samples.
产品编号 ABIN6945098
发货至: 中国
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中国
北京 101111
No. 88 KeChuang 6th Street
Beijing Economic Technological Development Area
Room 801-803
4A Biotech Co.,Ltd.
Tel +86 (0512) 65829739 传真 +86 (010) 6788 5057

Quick Overview for SUN1 抗体 (ABIN6945098)

抗原

See all SUN1 抗体
SUN1 (Sad1 and UNC84 Domain Containing 1 (SUN1))

适用

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人, 大鼠

宿主

  • 30
  • 4

克隆类型

  • 22
  • 12
单克隆

标记

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This SUN1 antibody is un-conjugated

应用范围

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  • 1
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Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

克隆位点

2C4
  • 交叉反应

    人, 大鼠

    纯化方法

    Purified by Protein A.

    免疫原

    Recombinant protein corresponding to C-terminal human SUN1.

    亚型

    IgG
  • 应用备注

    WB 1:300-5000
    FCM 1:20-100
    IHC-P 1:200-400
    IF(IHC-P) 1:50-200
    IF(ICC) 1:50-200

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    1 μg/μL

    缓冲液

    Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.

    储存液

    ProClin

    注意事项

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    Store at -20°C for 12 months.

    有效期

    12 months
  • 抗原

    SUN1 (Sad1 and UNC84 Domain Containing 1 (SUN1))

    别名

    SUN1

    背景

    Synonyms: SUN domain-containing protein 1, Protein unc-84 homolog A, Sad1/unc-84 protein-like 1, SUN1, KIAA0810, UNC84A

    Background: As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration. Involved in telomere attachment to nuclear envelope in the prophase of meiosis implicating a SUN1/2:KASH5 LINC complex in which SUN1 and SUN2 seem to act at least partial redundantly. Required for gametogenesis and involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis. Helps to define the distribution of nuclear pore complexes (NPCs). Required for efficient localization of SYNE4 in the nuclear envelope. May be involved in nuclear remodeling during sperm head formation in spermatogenenis. May play a role in DNA repair by suppressing non-homologous end joining repair to facilitate the repair of DNA cross-links.

    基因ID

    23353

    UniProt

    O94901

    途径

    Maintenance of Protein Location
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