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SPTAN1 抗体

This anti-SPTAN1 antibody is a 兔 单克隆 antibody detecting SPTAN1 in WB 和 IHC (p). Suitable for 人, 小鼠 和 大鼠.
产品编号 ABIN6945043
发货至: 中国

Quick Overview for SPTAN1 抗体 (ABIN6945043)

抗原

See all SPTAN1 抗体
SPTAN1 (Spectrin alpha Chain, Brain (SPTAN1))

适用

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人, 小鼠, 大鼠

宿主

  • 128
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克隆类型

  • 120
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单克隆

标记

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This SPTAN1 antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

克隆位点

4C8
  • 交叉反应

    人, 小鼠, 大鼠

    纯化方法

    Purified by Protein A.

    免疫原

    Recombinant protein within human Alpha Fodrin aa 2300-2450

    亚型

    IgG
  • 应用备注

    WB 1:300-5000
    IHC-P 1:200-400

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    1 μg/μL

    缓冲液

    Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.

    储存液

    ProClin

    注意事项

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    储存方法

    Store at 4°C for up to 2 weeks. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

    有效期

    12 months
  • 抗原

    SPTAN1 (Spectrin alpha Chain, Brain (SPTAN1))

    别名

    SPTAN1

    背景

    Synonyms: Spectrin alpha chain non-erythrocytic 1, Alpha-II spectrin, Fodrin alpha chain, Spectrin non-erythroid alpha subunit, NEAS, SPTA2,

    Background: Spectrins are a family of filamentous cytoskeletal proteins that function as essential scaffold proteins that stabilize the plasma membrane and organize intracellular organelles. Spectrins are composed of alpha and beta dimers that associate to form tetramers linked in a head-to-head arrangement. SPTAN1 is an alpha spectrin that is specifically expressed in nonerythrocytic cells. The encoded protein has been implicated in other cellular functions including DNA repair and cell cycle regulation. Mutations in this gene are the cause of early infantile epileptic encephalopathy-5. Alternate splicing results in multiple transcript variants. SPTAN1, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus a candidate for the calcium-dependent movement of the cytoskeleton at the membrane.

    基因ID

    6709

    UniProt

    Q13813

    途径

    Caspase Cascade in Apoptosis, Regulation of Actin Filament Polymerization
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